Immobilized anticancer agents and metal nanoparticles in a matrix of gellan: achievements and prospects
| Autor: | Sarkyt Kudaibergenov, Gulnur S. Tatykhanova, Zhanar A. Nurakhmetova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
plasmon photothermal therapy
02 engineering and technology General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Gellan gum gold nanoparticles and nanorods 0104 chemical sciences lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry polysaccharide immobilization sol-gel transition 0210 nano-technology gellan gum Nuclear chemistry |
| Zdroj: | Chemical Bulletin of Kazakh National University, Iss 4, Pp 32-41 (2020) |
| ISSN: | 2312-7554 |
| Popis: | A review is devoted to recent achievements in development of anticancer drugs based on natural polysaccharide – gellan that possesses coil-helix conformational transition, sol-gel phase transition, thermo- and salt sensitivity. The characteristics of high- and low-acyl gellan are briefly given and the influence of mono- and multivalent metal ions on the gelation efficiency is described. The mucoadhesive properties of gellan and its modified derivatives are briefly considered in the context of application in pharmacy as oral, buccal, nasal, ophthalmologic, vaginal forms. The main attention is paid to anticancer drugs, gold and silver nanoparticles immobilized within gellan matrix by chemical bonds, physical adsorption and chemosorption. The state-of-the art and perspectives of development of plasmonic photothermal therapy of cancer cells that is one of the promising direction of nanomedicine in diagnosis and treatment of oncological diseases are highlighted. It is outlined that the further strategy of development and application of plasmonic photothermal therapy into clinical practice is due to selection of metal nanoparticles with optimal sizes, high concentration, low cytotoxicity and suitable optical characteristics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|