A palm-sized high-sensitivity near-infrared fluorescence imager for laparotomy surgery
| Autor: | Jean-Luc Coll, Stephanie Guillermet, Christian Righini, Norman Mangeret, Philippe Rizo, Patrick Poulet, Paul Dorval, Ihab Atallah, Gabriele Barabino |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Polymers medicine.medical_treatment General Physics and Astronomy 01 natural sciences Mice chemistry.chemical_compound 0302 clinical medicine Limit of Detection Laparotomy Lymphedema Optical Fibers Spectroscopy Near-Infrared Liver Neoplasms Equipment Design General Medicine Surgery Computer-Assisted Head and Neck Neoplasms 030220 oncology & carcinogenesis Female Colorectal Neoplasms Palm Diagnostic Imaging Indocyanine Green medicine.medical_specialty Biophysics Mice Nude Near infrared fluorescence Fluorescence Fluorescence image-guided surgery 010309 optics 03 medical and health sciences 0103 physical sciences medicine Animals Hepatectomy Humans Radiology Nuclear Medicine and imaging Fluorescent Dyes Miniaturization business.industry Reproducibility of Results medicine.disease Surgery chemistry Molecular imaging business Indocyanine green Neoplasm Transplantation |
| Zdroj: | Physica Medica. 32:218-225 |
| ISSN: | 1120-1797 |
| DOI: | 10.1016/j.ejmp.2015.11.006 |
| Popis: | In laparotomy surgery guided by near-infrared fluorescence imaging, the access to the field of operation is limited by the illumination and/or the imaging field. The side of cavities or organs such as the liver or the heart cannot be examined with the systems available on the market, which are too large and too heavy. In this article, we describe and evaluate a palm sized probe, whose properties, weight, size and sensitivity are adapted for guiding laparotomy surgery. Different experiments have been performed to determine its main characteristics, both on the illumination and imaging sides. The device has been tested for fluorescent molecular probe imaging in preclinical procedures, to prove its ability to be used in cancer nodule detection during surgery. This system is now CE certified for clinical procedures and Indocyanine Green imaging has been performed during clinical investigations: lymphedema and surgical resection of liver metastases of colorectal cancers. |
| Databáze: | OpenAIRE |
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