Standardized herbal extract PM014 alleviates fine dust-induced lung inflammation in mice
| Autor: | Jun Young Lee, Seon-Young Park, Daeun Min, Hyunsu Bae, Ye-Seul Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment Population Inflammation Chung-sang-Bo-ha-tang Mice 03 medical and health sciences 0302 clinical medicine Republic of Korea medicine Animals Respiratory system education Inhalation Exposure Bronchus education.field_of_study Lung medicine.diagnostic_test pm10 Plant Extracts business.industry Dust Pneumonia lcsh:Other systems of medicine respiratory system medicine.disease lcsh:RZ201-999 respiratory tract diseases Mice Inbred C57BL Disease Models Animal Fine dust 030104 developmental biology medicine.anatomical_structure Cytokine Bronchoalveolar lavage BALF Complementary and alternative medicine PM014 030220 oncology & carcinogenesis Female medicine.symptom business Infiltration (medical) Research Article |
| Zdroj: | BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-8 (2020) BMC Complementary Medicine and Therapies |
| ISSN: | 2662-7671 |
| Popis: | Background Fine dust penetrates deep into the human alveoli, and the fine dust accumulated in the bronchus and lungs can directly trigger various respiratory diseases. PM014 (HL301) is the herbal extract derived from the herbal medicine Chung-Sang-Bo-Ha-Tang which is used for the treatment of lung diseases. Methods To evaluate the effect of PM014 on the lung inflammation induced by fine dust, this study investigated inflammatory responses in the lung upon pm10 exposure by examining the infiltration of inflammatory cell profiles from bronchial alveolar lavage fluid (BALF), lung histology, and production of pro-inflammatory cytokines measured by RT-PCR and ELISA. Results PM014-treated mice exhibited reduced lung tissue damage and inflammatory cell infiltration. Bronchoalveolar lavage fluid (BALF) analysis showed significant decrease in the population of total cells, macrophages, eosinophils, and neutrophils in PM014-treated mice. PM014 treatment downregulated the pro-inflammatory cytokine expressions including IL-1b, IL-8, IL-6, TNF-alpha, IL-21 and IL-17. ELISA analysis also showed reduced production of IL-1b, IL-6 and IL-17 in PM014-treated mice. Conclusion PM014 suppressed the pm10-induced inflammatory response in mice. This study shows that PM014 is a possible therapeutic agent for lung inflammation induced by fine dust. |
| Databáze: | OpenAIRE |
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