Inhibition Patterns the Whisking Rhythm
| Autor: | Carl C.H. Petersen, Varun Sreenivasan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Periodicity animal structures Movement Biology Inhibitory postsynaptic potential Reticular formation Article 03 medical and health sciences 0302 clinical medicine Rhythm Rhythmic inhibition medicine Animals Motor Neurons General Neuroscience Whisking in animals 030104 developmental biology medicine.anatomical_structure nervous system Vibrissae Neuron Brainstem Neuroscience 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Neuron. 90:211-213 |
| ISSN: | 0896-6273 |
| Popis: | Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad and snout movements, as well as for the bilateral synchronization of whisking. |
| Databáze: | OpenAIRE |
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