| Autor: |
Elif Öztürk Er, Sezin Erarpat, Süleyman Bodur, Ömer Tahir Günkara, Belma Özbek, Sezgin Bakırdere |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of chromatography. A. 1667 |
| ISSN: |
1873-3778 |
| Popis: |
The determination of amino acids in biological samples is central to the diagnosis of inherited metabolic disorders and also gives significant information about the metabolisms in the cells and living body. The development of analytical method for reliable quantification of amino acids in biological samples is still challenging because of the polar nature of amino acids and complex nature of biological samples causing a high degree of interferences during analysis. In the present study, a pre-column derivatization method using 2-naphtoyl chloride combined with liquid chromatography-tandem mass spectrometry method was developed for the determination of 17 amino acids in human serum and urine matrices. Low detection limits were obtained in the range of 0.015 - 0.266 µmol kg |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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