Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients
| Autor: | Yeison Harvey Carlosama-Rosero, H.J. Bolaños-Bravo, C.H. Sierra-Tórres, C.P. Acosta-Astaiza |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Genotype Population Colombia Gastroenterology Helicobacter Infections Bacterial Proteins Stomach Neoplasms Internal medicine medicine Humans CagA Risk factor education Antigens Bacterial education.field_of_study Helicobacter pylori biology business.industry Cancer General Medicine Middle Aged biology.organism_classification medicine.disease digestive system diseases Dysplasia Case-Control Studies Gastritis medicine.symptom business |
| Zdroj: | Revista de gastroenterologia de Mexico (English). |
| ISSN: | 2255-534X |
| Popis: | INTRODUCTION AND AIMS Colombia has high incidence levels of gastric cancer that can be explained by the genetic variability of Helicobacter pylori (H. pylori). Our aim was to establish the relation of the H. pylori CagA and VacA genotypes to dysplasia and gastric cancer, in a high-risk population. MATERIAL AND METHODS A case-control study was conducted on 202 patients from a high-risk cancer zone. Patients with dysplasia and gastric cancer (cases) and patients with nonatrophic gastritis (controls) were included. Endoscopic sampling and histologic classification were carried out according to the Sydney system and the Lauren classification. Genetic information was obtained through polymerase chain reaction on paraffin blocks. The measures of association of the variables of interest were evaluated in bivariate and multivariate models. A P |
| Databáze: | OpenAIRE |
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