Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation
Autor: | Marc Diederich, Marie Hélène Teiten, Chee Yan Choo, Sébastien Chateauvieux, Shéhérazade Hajjouli, Barbora Orlikova, Marc Schumacher, Mario Dicato |
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Rok vydání: | 2014 |
Předmět: |
MAPK/ERK pathway
Programmed cell death eurycomanol proliferation Cell Pharmaceutical Science Pharmacology Jurkat cells Article NF-κB Analytical Chemistry lcsh:QD241-441 Jurkat Cells eurycomanone Eurycoma longifolia Jack cell death lcsh:Organic chemistry Drug Discovery medicine Humans Eurycoma Physical and Theoretical Chemistry Cell Proliferation Inflammation Leukemia Quassins biology Plant Extracts Organic Chemistry NF-kappa B biology.organism_classification IκBα medicine.anatomical_structure Biochemistry Chemistry (miscellaneous) Leukocytes Mononuclear Molecular Medicine Eurycoma longifolia Signal transduction Signal Transduction K562 cells |
Zdroj: | Molecules, Vol 19, Iss 9, Pp 14649-14666 (2014) Molecules; Volume 19; Issue 9; Pages: 14649-14666 Molecules |
ISSN: | 1420-3049 |
DOI: | 10.3390/molecules190914649 |
Popis: | Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-κB signaling through inhibition of IκBα phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol. In conclusion, both quassinoids present differential toxicity towards leukemia cells, and the presence of the α,β-unsaturated ketone in eurycomanone could be prerequisite for the NF-κB inhibition. |
Databáze: | OpenAIRE |
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