microRNAs deregulation in head and neck squamous cell carcinoma
| Autor: | Caroline Torricelli, Janet Keller Silva, Gustavo Jacob Lourenço, Manoela M. Ortega, Carmen Silvia Passos Lima, Gabriela S. R. Queiroz, Juliana Carron |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
03 medical and health sciences 0302 clinical medicine Gene expression microRNA medicine Biomarkers Tumor Humans Epigenetics business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Cancer Cell cycle medicine.disease Head and neck squamous-cell carcinoma Gene expression profiling Gene Expression Regulation Neoplastic stomatognathic diseases MicroRNAs 030104 developmental biology Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell business |
| Zdroj: | HeadneckREFERENCES. 43(2) |
| ISSN: | 1097-0347 |
| Popis: | Head and neck (HN) squamous cell carcinoma (SCC) is the eighth most common human cancer worldwide. Besides tobacco and alcohol consumption, genetic and epigenetic alterations play an important role in HNSCC occurrence and progression. microRNAs (miRNAs) are small noncoding RNAs that regulate cell cycle, proliferation, development, differentiation, and apoptosis by interfering in gene expression. Expression profiling of miRNAs showed that some miRNAs are upregulated or downregulated in tumor cells when compared with the normal cells. The present review focuses on the role of miRNAs deregulations in HNSCC, enrolled in risk, development, outcome, and therapy sensitivity. Moreover, the influence of single nucleotide variants in miRNAs target sites, miRNAs seed sites, and miRNAs-processing genes in HNSCC was also revised. Due to its potential for cancer diagnosis, progression, and as a therapeutic target, miRNAs may bring new perspectives in HNSCC understanding and therapy, especially for those patients with no or insufficient treatment options. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text