Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis
| Autor: | S, Brennan, P D, Sly, C L, Gangell, N, Sturges, K, Winfield, M, Wikstrom, S, Gard, J W, Upham, C F, Robertson |
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| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Cystic Fibrosis CCL4 Cell Count Cystic fibrosis Bronchoalveolar Lavage Macrophages Alveolar medicine Humans Respiratory system Macrophage inflammatory protein Chemokine CCL5 Lung Respiratory Tract Infections Chemokine CCL2 medicine.diagnostic_test business.industry Monocyte Respiratory disease Infant Macrophage Inflammatory Proteins medicine.disease medicine.anatomical_structure Bronchoalveolar lavage Case-Control Studies Child Preschool Immunology Alveolar macrophage Female business |
| Zdroj: | The European respiratory journal. 34(3) |
| ISSN: | 1399-3003 |
| Popis: | Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease. Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms. Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223x10(3) versus 85x10(3) cells.mL(-1); p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3alpha (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg.mL(-1); p |
| Databáze: | OpenAIRE |
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