Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds
| Autor: | Radha Santonocito, Fiorenza Provenzano, Pier Luigi San Biagio, Maria Antonietta Sabatino, Estella Rao, Romano Lapasin, Rosa Passantino, Lorena Anna Ditta, Maria Assunta Costa, Daniela Giacomazza, Clelia Dispenza, Jesús Lozano Sánchez |
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| Přispěvatelé: | Ditta L.A., Rao E., Provenzano F., Sanchez J.L., Santonocito R., Passantino R., Costa M.A., Sabatino M.A., Dispenza C., Giacomazza D., San Biagio P.L., Lapasin R. |
| Rok vydání: | 2020 |
| Předmět: |
Chronic wound
Cell Survival 02 engineering and technology Carrageenan Biochemistry Antioxidants 03 medical and health sciences chemistry.chemical_compound Mice Structural Biology medicine Glycerol Animals Fibroblast Cytotoxicity Molecular Biology 030304 developmental biology 0303 health sciences Epidermis (botany) Plant Extracts Sepharose General Medicine Fibroblasts 021001 nanoscience & nanotechnology Methylgalactosides Bandages Bryopsida Elasticity Biomechanical Phenomena medicine.anatomical_structure Agarose/κ-carrageenan lend Cryphaea heteromalla bryophyte Wound healing chemistry Self-healing hydrogels Biophysics NIH 3T3 Cells Agarose Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie medicine.symptom Swelling 0210 nano-technology |
| Zdroj: | International journal of biological macromolecules. 164 |
| ISSN: | 1879-0003 |
| Popis: | Hydrogels for complex and chronic wound dressings must be conformable, absorb and retain wound exudates and maintain hydration. They can incorporate and release bioactive molecules that can accelerate the healing process. Wound dressings have to be in contact with the wound and epidermis, even for long periods, without causing adverse effects. Hydrogel dressing formulations based on biopolymers derived from terrestrial or marine flora can be relatively inexpensive and well tolerated. In the present article hydrogel films composed by agarose (1.0 wt%), κ-carrageenan at three different concentrations (0.5, 1.0 and 1.5 wt%) and glycerol (3.0 wt%) were prepared without recourse to crosslinking agents, and characterized for their mechanical properties, morphology, swelling and erosion behavior. The films resulted highly elastic and able to absorb and retain large amounts of fluids without losing their integrity. One of the films was loaded with the aqueous extract from Cryphaea heteromalla (Hedw.) D. Mohr for its antioxidant properties. Absence of cytotoxicity and ability to reduce the oxidative stress were demonstrated on NIH-3T3 fibroblast cell cultures. These results encourage further biological evaluations to assess their impact on the healing process. |
| Databáze: | OpenAIRE |
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