Increased oxidative stress in childhood atopic dermatitis
| Autor: | Mitsufumi Mayumi, Mizu Jiang, Akiko Yamada, Mokoto Yasutomi, Masahiro Hiraoka, Hirokazu Tsukahara, Yusei Ohshima, Nemuko Omata, Yoji Deguchi, Setsuko Ito, Mitsuhiko Nambu |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Adolescent Urinary system Enzyme-Linked Immunosorbent Assay medicine.disease_cause General Biochemistry Genetics and Molecular Biology Dermatitis Atopic Nitric oxide Selenium chemistry.chemical_compound medicine Homeostasis Humans Deoxyguanosine General Pharmacology Toxicology and Pharmaceutics Nitrite Child Nitrites Nitrates 8-Hydroxy-2'-deoxyguanosine General Medicine Atopic dermatitis medicine.disease Oxidative Stress chemistry 8-Hydroxy-2'-Deoxyguanosine Child Preschool Immunology Female Oxidative stress |
| Zdroj: | Life Sciences. 69:223-228 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(01)01124-9 |
| Popis: | Atopic dermatitis (AD) is a chronic inflammatory skin disease of unknown etiology. To examine the involvement of impaired homeostasis of oxygen/nitrogen radicals in childhood AD, we compared the levels of urinary 8-hydroxy-2'-deoxyguanosine (marker of oxidative stress), nitrite/nitrate (marker of nitric oxide synthesis) and selenium (marker of selenium store) in 27 children with AD to those of 25 healthy control children. Urinary 8-hydroxy-2'-deoxyguanosine was significantly higher and nitrite/nitrate levels were significantly lower in patients with AD than in the control. Urinary selenium levels were similar in both groups. Our findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD. |
| Databáze: | OpenAIRE |
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