Terpenoid biotransformation in mammals IV Biotransformation of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid in rabbits
| Autor: | Yoshinori Asakawa, Tsunematsu Takemoto, Masao Toyota, T. Ishida |
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| Rok vydání: | 1986 |
| Předmět: |
Polycyclic Sesquiterpenes
Pharmacology Health Toxicology and Mutagenesis Caryophyllene Epoxide General Medicine Phenanthrenes Primary alcohol Toxicology Sesquiterpene Biochemistry chemistry.chemical_compound chemistry Biotransformation Abietanes Nootkatone Animals Organic chemistry Rabbits Diterpenes Longifolene Abietic acid Sesquiterpenes |
| Zdroj: | Xenobiotica. 16:753-767 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498258609043566 |
| Popis: | 1. The metabolism of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydro-abietic acid was studied in rabbits.2. Each of these sesquiterpenoids was converted to primary, secondary or tertiary alcohols, among which the primary alcohol was predominant.3. A vinylic methyl group and an exomethylene group were easily hydroxylated and converted to a glycol via an epoxide in many cases.4. Eight new metabolites were determined by chemical and spectroscopic methods. |
| Databáze: | OpenAIRE |
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