Syphilitic uveitis in patients infected with human immunodeficiency virus

Autor: Nathalie Cassoux, Phuc LeHoang, Thi Ha Chau Tran, Bahram Bodaghi, Christine Fardeau, Eric Caumes
Přispěvatelé: Service d'Ophtalmologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], Saidi, Vanessa
Rok vydání: 2005
Předmět:
Male
Visual acuity
HIV Infections
MESH: Penicillin G
Eye Infections
Bacterial
0302 clinical medicine
Risk Factors
MESH: Incidence
030212 general & internal medicine
Fluorescein Angiography
MESH: Middle Aged
MESH: Eye Infections
Bacterial
Incidence
Ceftriaxone
Panuveitis
Penicillin G
Retinal Necrosis Syndrome
Acute
Homosexuality
MESH: HIV Infections
Middle Aged
MESH: Homosexuality
MESH: Fluorescein Angiography
Sensory Systems
Anti-Bacterial Agents
3. Good health
[SDV.IB]Life Sciences [q-bio]/Bioengineering
medicine.symptom
Uveitis
medicine.drug
Adult
medicine.medical_specialty
Retinitis
MESH: Retinal Necrosis Syndrome
Acute
03 medical and health sciences
Cellular and Molecular Neuroscience
MESH: Anti-Bacterial Agents
medicine
Humans
Syphilis
MESH: Chorioretinitis
MESH: Ris
Retrospective Studies
[SDV.IB] Life Sciences [q-bio]/Bioengineering
MESH: Humans
business.industry
Chorioretinitis
MESH: Adult
MESH: Retrospective Studies
Eye infection
medicine.disease
Dermatology
MESH: Male
MESH: Ceftriaxone
Penicillin
Ophthalmology
Immunology
030221 ophthalmology & optometry
business
Zdroj: Albrecht von Graefe s Archiv für Ophthalmologie
Albrecht von Graefe s Archiv für Ophthalmologie, 2005, 243 (9), pp.863-9. ⟨10.1007/s00417-005-1137-6⟩
ISSN: 1435-702X
0721-832X
DOI: 10.1007/s00417-005-1137-6
Popis: BACKGROUND: This work investigates the incidence and clinical features of syphilitic uveitis in patients infected with human immunodeficiency virus (HIV). MATERIAL AND METHODS: We retrospectively reviewed syphilitic uveitis in patients coinfected with HIV that presented at a referral center between July 2001 and November 2003. RESULTS: Twelve patients (20 eyes) were included. The ocular manifestations of syphilis led to the discovery of HIV-1 seropositivity in three patients. All patients were male and homosexual. One patient has been previously treated for syphilis with benzathine penicillin G. One patient presented with anterior uveitis and 11 patients had panuveitis or posterior uveitis. Necrotizing retinitis was noted in seven eyes (35%), posterior placoid chorioretinitis in six eyes (30%) and optic nerve involvement in five eyes (25%). Of nine patients with available cerebrospinal fluid (CSF) studies, seven (77.8%) had CSF abnormalities. Eleven patients were treated with intravenous penicillin G and one with intravenous ceftriaxone sodium. One patient required a second course of antibiotics to control uveitis. Ocular inflammation decreased and visual acuity improved in all nine patients for whom follow-up was available after treatment. CONCLUSION: Manifestations of syphilitic uveitis in HIV-infected patients are multiple, with high frequencies of posterior uveitis, posterior placoid chorioretinitis, necrotizing retinitis and optic nerve involvement. Syphilitic uveitis in HIV-infected patients seems to have a more severe course and may relapse despite high-dose intravenous penicillin therapy.
Databáze: OpenAIRE
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