The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

Autor: Franco Js, Adriana Rojas-Villarraga, Juan-Manuel Anaya, Rubén D. Mantilla, Yeny Acosta-Ampudia, Mónica Rodríguez-Jiménez, Jenny Amaya-Amaya, Nicolás Molano-González
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Phospholipid antibody
Epidemiology
Factor reumatoide
lcsh:Medicine
Síndrome antifosfolípido
Autoimmunity
Autoimmune hepatitis
Disease
Primary biliary cirrhosis
immune system diseases
Risk Factors
Antiphospholipid syndrome
Medicine and Health Sciences
Lupus Erythematosus
Systemic
lcsh:Science
skin and connective tissue diseases
Antibody titer
Multidisciplinary
Adulto
Rheumatoid factor
Middle Aged
Antiphospholipid Syndrome
Rheumatoid arthritis
Female
Systemic vasculitis
Research Article
Adult
medicine.medical_specialty
Anticuerpo fosfolípido
Immunology
Colombia
Systemic Lupus Erythematosus
Autoimmune Diseases
Rheumatology
Internal medicine
Lupus eritematoso sistémico
medicine
Humans
Demography
Lupus erythematosus
Lupus Erythematosus
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Enfermedades
Enfermedades del sistema inmunológico
Multivariate Analysis
lcsh:Q
Clinical Immunology
business
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e110242 (2014)
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
ISSN: 1932-6203
Popis: Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al.
Databáze: OpenAIRE
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