Relevance of hyperglycemia to early mechanical hyperalgesia in streptozotocin-induced diabetes
| Autor: | Stephanie L. Hastings, Joseph R. Stimers, Maxim Dobretsov, Dmitry Romanovsky |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Male Pain Threshold medicine.medical_specialty endocrine system diseases Hindlimb Carbohydrate metabolism Diabetes Mellitus Experimental Rats Sprague-Dawley Physical Stimulation Internal medicine Diabetes mellitus Randall–Selitto test medicine Animals Insulin Glucose tolerance test medicine.diagnostic_test business.industry General Neuroscience nutritional and metabolic diseases Streptozotocin medicine.disease Rats Endocrinology Nociception Hyperalgesia Hyperglycemia Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of the Peripheral Nervous System. 9:62-69 |
| ISSN: | 1529-8027 1085-9489 |
| DOI: | 10.1111/j.1085-9489.2004.009204.x |
| Popis: | A modified von Frey filament test and an algesiometer paw pressure test were used to measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and rats injected with streptozotocin (STZ, 50 mg/kg). STZ treatment induced hyperglycemia (HG rats) in about 40% of treated animals. The rest of the STZ-treated and control rats remained normoglycemic (NG rats) throughout the entire experiment. No indications of mechanical hyperalgesia were observed in control groups of animals injected with physiological buffer only. However, both the behavioral tests used detected a 15-30% decrease in the mechanical nociceptive threshold of rats treated with STZ. Furthermore, mechanical nociceptive threshold changes were statistically indistinguishable between NG and HG rats. Glucose tolerance test did not reveal abnormalities of glucose metabolism in NG rats (compared to control animals). However, 1 week after STZ injection, the serum insulin level of NG rats was significantly lower than that of age-matched control rats (0.81 +/- 0.16 vs. 3.5 +/- 0.4 ng/mL; p < 0.01). These data strongly argue that systemic hyperglycemia is not the only factor triggering the development of mechanical hyperalgesia in the STZ rat model of diabetes. Other than hyperglycemia, consequences of insulinemia or insulinemia itself may play an important role in early impairment of mechanical nociception in this animal model. |
| Databáze: | OpenAIRE |
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