The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union
| Autor: | Stan Jones, James A. Fernandes, Madhavan C. Papanna, K.A.N. Saldanha, Binu T Kurian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
030222 orthopedics
medicine.medical_specialty Bone union business.industry medicine.medical_treatment Mean age Non union Surgery 03 medical and health sciences Congenital abnormalities non-union 0302 clinical medicine Orthopedic surgery medicine Internal fixation Orthopedics and Sports Medicine Original Article Adverse effect business Bone rhBMP-2 030217 neurology & neurosurgery |
| Zdroj: | Strategies in Trauma and Limb Reconstruction |
| ISSN: | 1828-8928 1828-8936 |
| Popis: | The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4-15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application. Patients had undergone a mean of 2 (1-5) operations prior to implantation of rhBMP-2. All the patients in the study group were available for review with mean follow-up of 44 months (range 21-70). The mean time to union was 16 weeks (range 10-28 weeks). No adverse events related to BMP-2 application were noted in our study group. Healing occurred clinically and radiographically in 16 of the 17 sites. Our study demonstrates that BMP-2 enhances healing of the persistent non-unions without any adverse events. |
| Databáze: | OpenAIRE |
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