In utero exposure to fluoride and cognitive development delay in infants
| Autor: | Y. Alcaraz Contreras, O.D. López Guzmán, Diana Rocha-Amador, R. Costilla-Salazar, J. Calderón Hernández, M. Cervantes Flores, L. Valdez Jiménez |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Developmental Disabilities 010501 environmental sciences Toxicology 01 natural sciences Bayley Scales of Infant Development 03 medical and health sciences chemistry.chemical_compound Fluorides Young Adult 0302 clinical medicine Pregnancy 030225 pediatrics medicine Humans Mexico 0105 earth and related environmental sciences Psychomotor learning Obstetrics business.industry General Neuroscience Confounding Gestational age Infant Environmental exposure medicine.disease Cariostatic Agents chemistry In utero Maternal Exposure Prenatal Exposure Delayed Effects Female business Cognition Disorders Fluoride |
| Zdroj: | Neurotoxicology. 59 |
| ISSN: | 1872-9711 |
| Popis: | The objective of this study was to evaluate the association between in utero exposure to fluoride (F) and Mental and Psychomotor Development (MDI and PDI) evaluated through the Bayley Scale of Infant Development II (BSDI-II) in infants. The sample included 65 mother-infant pairs. Environmental exposure to F was quantified in tap and bottled water samples and F in maternal urine was the biological exposure indicator; samples were collected during the 1st, 2nd and 3rd trimester of pregnancy. The mean values of F in tap water for the 1st, 2nd and 3rd trimester were 2.6±1.1mg/l, 3.1±1.1mg/l and 3.7±1.0mg/l respectively; above to 80% of the samples exceeded the reference value of 1.5mg/l (NOM-127-SSA1-1994). Regarding F in maternal urine, mean values were 1.9±1.0mg/l, 2.0±1.1mg/l and 2.7±1.1mg/l for the 1st, 2nd and 3rd trimester respectively. The infants with MDI and PDI scores less than 85 points were 38.5% and 20.9% respectively. After adjusting for potential confounding factors (gestational age, age of child, marginalization index and type of water for consumption), the MDI showed an inverse association with F levels in maternal urine for the first (β=-19.05, p=0.04) and second trimester (β=-19.34, p=0.01). Our data suggests that cognitive alterations in children born from exposed mothers to F could start in early prenatal stages of life. |
| Databáze: | OpenAIRE |
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