Aberrant hypermethylation of the FGFR2 gene in human gastric cancer cell lines
| Autor: | Jun-Hyeog Jang, Soonok Park, Ji-Hyun Kim |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities Biophysics DNA Methyltransferase Inhibitor Biology Biochemistry Stomach Neoplasms Cell Line Tumor medicine Humans Cancer epigenetics Receptor Fibroblast Growth Factor Type 2 Molecular Biology integumentary system Fibroblast growth factor receptor 2 Cancer Promoter Cell Biology Methylation DNA Neoplasm DNA Methylation medicine.disease Molecular biology Gene Expression Regulation Neoplastic stomatognathic diseases Tumor progression embryonic structures DNA methylation Mutation Cancer research DNA Damage |
| Zdroj: | Biochemical and biophysical research communications. 357(4) |
| ISSN: | 0006-291X |
| Popis: | We have previously shown that fibroblast growth factor receptor 2 (FGFR2) plays an important role in gastric carcinogenesis. In this study, we assessed DNA methylation status in the promoter region of FGFR2 gene in gastric cancer cell lines, and indicated that this region was highly methylated, compared with FGFR2-expressing gastric cancer cell lines. Moreover, the restoration of FGFR2 expression by treating methylated cells with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine strongly suggests that the loss of FGFR2 expression may be due to the aberrant hypermethylation in the promoter region of the FGFR2 gene. Thus, our results suggest that the epigenetic silencing of FGFR2 through DNA methylation in gastric cancer may contribute to tumor progression. |
| Databáze: | OpenAIRE |
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