Ultraviolet B-induced suppression of immune responses in interleukin-4-/- mice: relationship to dermal mast cells
| Autor: | Aleksandra Jaksic, Michele A. Grimbaldeston, John J. Finlay-Jones, Prue H. Hart, Gary M. Halliday, Georgina J. Swift, Emma K. Hosszu, Joy E Tan |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Ratón
Ultraviolet Rays Cell Cell Count Dermatology Picryl Chloride Biology Dermatitis Contact Biochemistry Cell Degranulation chemistry.chemical_compound Mice Immune system Antigen medicine Animals Hypersensitivity Delayed Mast Cells Molecular Biology Interleukin 4 Skin Cis-Urocanic Acid Cell Biology Mast cell Molecular biology Interleukin-10 Mice Inbred C57BL medicine.anatomical_structure chemistry Immunology Antibody Formation Interleukin-4 Histamine Spleen |
| Zdroj: | The Journal of investigative dermatology. 114(3) |
| ISSN: | 0022-202X |
| Popis: | Ultraviolet B radiation is immunosuppressive by multiple mechanisms. In interleukin-4–/– mice, ultraviolet B radiation was not able to suppress delayed-type hypersensitivity or contact hypersensitivity responses when the sensitizing antigen was applied to nonirradiated sites. In contrast, ultraviolet B significantly suppressed contact hypersensitivity responses to haptens applied to irradiated sites in interleukin-4–/– mice. In mast cell depleted Wf/Wf mice, ultraviolet B radiation also significantly suppressed contact hypersensitivity responses to sensitizing antigens applied to irradiated but not to unirradiated sites. In both interleukin-4–/– mice and Wf/Wf mice, the mast cell product, histamine, was immunosuppressive implicating mast cells as the dysfunctional cell in interleukin-4–/– mice. The prevalence of dermal mast cells was similar in wild-type and interleukin-4–/– mice. Dermal mast cells of interleukin-4–/– mice, however, express very low levels of c-kit and did not significantly degranulate in response to ultraviolet B. Ultraviolet radiation induced significant and similar levels of serum interleukin-10 in wild-type and interleukin-4–/– mice. We conclude that interleukin-4 indirectly affects ultraviolet B suppression of contact hypersensitivity and delayed-type hypersensitivity responses to sensitizing antigens applied at sites other than those irradiated by providing a critical differentiative signal for dermal mast cells. This study further emphasizes the central role of mast cells in the initial processes by which ultraviolet B radiation is immunomodulatory for immune responses to sensitizing antigens applied to nonirradiated sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|