Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
| Autor: | Carolina Q. Sacramento, Vinicius Cardoso Soares, Felipe Betoni Saraiva, Diogo A. Tschoeke, Marcelo Alves Ferreira, Aline de Paula Dias Da Silva, Danielle A. S. Rodrigues, Isaclaudia G. de Azevedo, Patrícia T. Bozza, João Gesto, Natalia Fintelman-Rodrigues, Fernando A. Bozza, Thiago Moreno L. Souza, Andre M. Vale, Monique Cristina dos Santos, Hui Jiang, Carlos M. Morel, Hongdong Tan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Epidemiology viruses 030231 tropical medicine Infectious and parasitic diseases RC109-216 Disease medicine.disease_cause Disease cluster reinfection 03 medical and health sciences respiratory infections 0302 clinical medicine Immune system Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2 Brazil Medicine Humans 030212 general & internal medicine Coronavirus First episode business.industry Host (biology) SARS-CoV-2 Research COVID-19 zoonoses Immunity Humoral Infectious Diseases coronavirus disease Humoral immunity Immunology next-generation sequencing business Viral load humoral response Brazil severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1446-1453 (2021) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented. |
| Databáze: | OpenAIRE |
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