Cellular and humoral immunity in patients infected with the SARS-CoV-2 virus at general hospital
| Autor: | Valéria Brandão, Ana Carolina Dos Santos, Grasiele Lima, Ana Karolina B. B. Marinho, Débora S. Guterres, Myrthes Toledo Barros, Marina de Almeida Prado Meireles Laubi, Sara Tencarte, Octavio Grecco, Cristina M. Kokron, Thaís T. Saito, Roselene Lourenço, Myrthes Toledo de Barros |
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| Rok vydání: | 2021 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty business.industry medicine.medical_treatment Immunology Selective IgA deficiency medicine.disease Intensive care unit Article Pathophysiology Virus law.invention Immune system law Internal medicine Intensive care Diabetes mellitus medicine Immunology and Allergy business |
| Zdroj: | The Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology |
| ISSN: | 0091-6749 |
| Popis: | Rationale: The cellular immune response seems to have a central role in the pathophysiology of COVID-19. Few studies have analyzed lymphocyte subpopulations and clinical outcomes. We evaluated clinical and immunological characteristics of patients infected with the SARS-CoV-2 virus and described the outcomes during hospitalization. Method(s): Prospective and descriptive study carried with adult patients, admitted with a diagnosis of COVID-19 confirmed by RT-PCR. We evaluated lymphocytes subsets (CD3+, CD4+, CD8+, CD19), serum immunoglobulin levels (IgG, IgM, IgA) and described the mean hospital stay outcomes, need for intensive care, mechanical ventilation and death. Result(s): Of the 165 patients included, 65% were male, with an average of 58.7 years. The most related initial symptoms were dyspnea (80%), fever (74%) and cough (70%). Among the reported comorbidities, 58% had obesity, 47% systemic arterial hypertension and 25% diabetes. We observed that 40% lymphopenia, 43% reduction in CD3+, 46% reduction in CD4+, 50% reduction in CD8+ and 39% reduction in CD19+. The average levels of IgG, IgM and IgA were 1,285, 121 and 296mg / dL, respectively. We identified 3 patients with selective IgA deficiency and all were discharged. Regarding the outcome, 28% required intensive care unit, 24% mechanical ventilation conditions and 23% of the patients died. Conclusion(s): Lymphopenia, reduction of CD8+, CD4+ and CD3+ cells were frequent in hospitalized patients, inferring greater clinical severity. However, we identified three patients with selective IgA deficiency whose outcome was hospital discharge.Copyright © 2020 |
| Databáze: | OpenAIRE |
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