Exploration of ToxCast/Tox21 bioassays as candidate bioanalytical tools for measuring groups of chemicals in water
Autor: | Louisse, Jochem, Dingemans, Milou M L, Baken, Kirsten A, van Wezel, Annemarie P, Schriks, Merijn, Environmental Sciences |
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Přispěvatelé: | Environmental Sciences |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Bioanalysis
Environmental Engineering Health Toxicology and Mutagenesis 0208 environmental biotechnology Water source Bioanalytical tools 02 engineering and technology 010501 environmental sciences 01 natural sciences Tox21 Water Quality Environmental Chemistry Bioassay 0105 earth and related environmental sciences Groups of chemicals Public Health Environmental and Occupational Health Chemical water quality Water General Medicine General Chemistry Pollution 020801 environmental engineering ToxCast Environmental chemistry Environmental science Biological Assay Water quality Water Pollutants Chemical Environmental Monitoring |
Zdroj: | Chemosphere, 209, 373. Elsevier |
ISSN: | 0045-6535 |
Popis: | The present study explores the ToxCast/Tox21 database to select candidate bioassays as bioanalytical tools for measuring groups of chemicals in water. To this aim, the ToxCast/Tox21 database was explored for bioassays that detect polycyclic aromatic hydrocarbons (PAHs), aromatic amines (AAs), (chloro)phenols ((C)Ps) and halogenated aliphatic hydrocarbons (HAliHs), which are included in the European and/or Dutch Drinking Water Directives. Based on the analysis of the availability and performance of bioassays included in the database, we concluded that several bioassays are suitable as bioanalytical tools for assessing the presence of PAHs and (C)Ps in drinking water sources. No bioassays were identified for AAs and HAliHs, due to the limited activity of these chemicals and/or the limited amount of data on these chemicals in the database. A series of bioassays was selected that measure molecular or cellular effects that are covered by bioassays currently in use for chemical water quality monitoring. Interestingly, also bioassays were selected that represent molecular or cellular effects that are not covered by bioassays currently applied. The usefulness of these newly identified bioassays as bioanalytical tools should be further evaluated in follow-up studies. Altogether, this study shows how exploration of the ToxCast/Tox21 database provides a series of candidate bioassays as bioanalytical tools for measuring groups of chemicals in water. This assessment can be performed for any group of chemicals of interest (if represented in the database), and may provide candidate bioassays that can be used to complement the currently applied bioassays for chemical water quality assessment. |
Databáze: | OpenAIRE |
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