O impacto na expressão agnors e apoptose na próstata do hamster-mesocricetus auratus (HMA) submetido à aplicação de finasterida
| Autor: | Felipe Eduardo Costa Vidigal, Alcino Lázaro da Silva, Dimas José Araújo Vidigal |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Programmed cell death
medicine.medical_specialty Urology lcsh:Surgery Hamster chemistry.chemical_compound Prostate medicine Finasterida biology Mesocricetus Cell growth business.industry Finasteride lcsh:RD1-811 Próstata biology.organism_classification Surgery medicine.anatomical_structure chemistry Apoptosis business |
| Zdroj: | Revista do Colégio Brasileiro de Cirurgiões, Vol 38, Iss 5, Pp 334-337 Revista do Colégio Brasileiro de Cirurgiões v.38 n.5 2011 Revista do Colégio Brasileiro de Cirurgiões Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
| ISSN: | 1809-4546 |
| Popis: | OBJECTIVE: To evaluate the impact on the AgNORs expression and apoptosis in the prostate of the hamster-Mesocricetus auratus (HMA) submitted to the application of finasteride. METHODS: Twenty male rodents of the species HMA (n = 20) were randomly assigned to groups of ten animals: Finasteride group (n = 10) and the Control group (n = 10). In the finasteride group 7.14 ng / mL finasteride was subcutaneously (SC) administered on the back of the animals three times a week for 90 days. AgNOR expression was evaluated as a marker of cell proliferation and apoptosis as a marker of cell death. RESULTS: The expression of AgNORs was lower in the finasteride group, 2.846 ± 0.877 vs. 3.68 ± 1.07 argyrophilic regions per square micrometer (µm2) in the control group, p = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|