Dose variation that is associated with approximated one-quarter tablet doses of misoprostol
| Autor: | John Baiano, George E. Davis, Mark C. Williams, John C.M. Tsibris, William F. O'Brien |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Obstetrics and Gynecology Surgery Uterine cervix Pregnancy Liquid chromatography mass spectroscopy Oxytocics Labor induction Pill medicine Humans Female Razor Blade business Misoprostol Chromatography High Pressure Liquid Tablets medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 187:615-619 |
| ISSN: | 0002-9378 |
| DOI: | 10.1067/mob.2002.124959 |
| Popis: | The purpose of this study was to evaluate dose variation in approximated one-quarter tablet misoprostol fragments.Misoprostol 100 microg tablets were weighed, separated into two lots, and quartered with a razor blade or a pill cutter. Fragments were reweighed, and the misoprostol content was determined by high-performance liquid chromatography mass spectroscopy.Fragment weights varied more when a pill cutter was used (P.0001). Fewer pill-cutter fragments than razor-cut fragments weighed within 10% of expected (24% vs 65%, P.0001). Misoprostol content among the fragments that were determined by high-performance liquid chromatography mass spectroscopy was 103% +/- 12% of expected (range, 73%-124%). Tablet fragments that weighedor=27.5 mg contained misoprostol in excess of 110% of expected in seven of eight fragments, although none from fragments that weighedor=26.5 mg did. Misoprostol was evenly distributed in all fragments that were assayed.Misoprostol is evenly distributed among tablet fragments. Accurate low-dose misoprostol cervical ripening is possible if the tablet fragments are individually weighed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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