Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction
| Autor: | Fei Deng, Yulong Li, Jin-Xia Wan, Jérôme Flakowski, Vincent Pascoli, Christian Lüscher, Linda D. Simmler, Katherine M. Nautiyal, Yue Li, Ruud van Zessen |
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| Rok vydání: | 2021 |
| Předmět: |
Receptor
Serotonin 5-HT1B / metabolism Serotonin Serotonin / metabolism media_common.quotation_subject Dopamine Mesolimbic dopamine Receptor Serotonin 5-HT1B / deficiency Optogenetics Citalopram Neurotransmission Synaptic Transmission Cocaine-Related Disorders Mice Cocaine medicine Animals Gene Knock-In Techniques Cocaine / administration & dosage media_common Mice Knockout Serotonin Plasma Membrane Transport Proteins Multidisciplinary Mechanism (biology) business.industry Addiction Cocaine-Related Disorders / genetics ddc:616.8 Serotonin Plasma Membrane Transport Proteins / metabolism Receptor Serotonin 5-HT1B business Neuroscience Cocaine-Related Disorders / metabolism Dopamine / metabolism medicine.drug |
| Zdroj: | Science, Vol. 373, No 6560 (2021) pp. 1252-1256 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Prevention of compulsive cocaine taking Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulnerability to drug addiction. However, the relevant circuits and underlying cellular processes remain elusive. Li et al . discovered a synaptic mechanism in mice that underlies the modulatory role of 5-HT in reducing the likelihood of transition to compulsion and eventually addiction (see the Perspective by Miyazaki and Miyazaki). Cocaine binds to 5-HT transporters to block 5-HT reuptake. The elevated extracellular 5-HT activates 5-HT 1B receptors and causes presynaptic depression of a projection from the orbitofrontal cortex to the dorsal striatum. These changes reduce the likelihood of inducing postsynaptic potentiation at these synapses, which ultimately drives compulsion. —PRS |
| Databáze: | OpenAIRE |
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