Prevalence of oncogenic human papillomavirus 16 and 18 in the palatine tonsils of the general adult population
| Autor: | Joel A. Ernster, Maureen M. O’Brien, Cosimo G. Sciotto, Linda J. Robinson, Thomas Willson |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorado Palatine Tonsil Prevalence Group A Palatine tonsil Group B Internal medicine Epidemiology medicine Carcinoma Humans Human papillomavirus 16 Paraffin Embedding Human papillomavirus 18 business.industry Incidence (epidemiology) Incidence Papillomavirus Infections HPV infection virus diseases General Medicine medicine.disease female genital diseases and pregnancy complications stomatognathic diseases Oropharyngeal Neoplasms Tonsillitis medicine.anatomical_structure Otorhinolaryngology Immunology Carcinoma Squamous Cell Surgery Female business |
| Zdroj: | Archives of otolaryngology--headneck surgery. 135(6) |
| ISSN: | 1538-361X |
| Popis: | Objective To determine whether there has been a demonstrable increase in the prevalence of human papillomavirus (HPV)–infected palatine tonsils corresponding to the increase in incidence of HPV-positive oropharyngeal squamous cell carcinoma (SCC) over time. Design Review of archived, paraffin-embedded, noncancerous palatine tonsils. Setting A single institution in El Paso County, Colorado. Patients Age- and sex-matched patients 21 years and older from 2 different periods: January 1, 1979, to December 31, 1982, (group A) and January 1, 1997, to December 31, 2001 (group B). Main Outcome Measures Prevalence of oncogenic HPV-16 and HPV-18 in noncancerous palatine tonsils in relation to the incidence of HPV-positive oropharyngeal SCC. Results All specimens in both groups were negative for HPV-16 and HPV-18. Thus, the prevalence of HPV infection in the palatine tonsils of the general adult population was zero in both group A and group B. Conclusions This analysis shows a low prevalence of HPV infection in the palatine tonsils of the general adult population in a single county in Colorado known to have an increasing rate of HPV-positive oropharyngeal SCC. Analysis of oropharyngeal tissues from individuals at highest risk of developing HPV-positive oropharyngeal SCC (middle-aged men) is likely to provide a higher prevalence rate. |
| Databáze: | OpenAIRE |
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