Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors
| Autor: | Montserrat Rabassa, David Fraile Navarro, Juan José Yepes-Nuñez, Jesse Kuindersma, Ignacio Ricci-Cabello, Alberto López García-Franco, Hector Pardo-Hernandez, Rocío Zamanillo Campos, Pablo Alonso-Coello, Carlos Canelo-Aybar, Ignasi Gich Saladich, Ena Niño de Guzmán, José Francisco Meneses-Echávez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Databases Factual Descriptive statistics business.industry Editorial independence media_common.quotation_subject Public health Vitamins General Medicine Guideline Quality appraisal Family medicine Quality Score Vitamin D and neurology Humans Medicine Quality (business) Vitamin D business media_common |
| Zdroj: | International Journal of Clinical Practice. 75 |
| ISSN: | 1742-1241 1368-5031 |
| DOI: | 10.1111/ijcp.14805 |
| Popis: | Background Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and explore predictive factors for their direction and strength. Methods We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. Results We included 34 guidelines, 44.1% recommended, 26.5% suggested, and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs. 35.4; p=0.001), and median 58.3 vs. 37.5; p=0.02). Guidance produced by government organizations and those that reported source of funding were associated with higher AGREE II scores. Unclear role of source of funding was associated with recommending or suggesting vitamin D supplementation (p=0.034). Editorial independence was an independent predictor for recommending or suggesting vitamin D supplementation (OR 1.09; CI95% 1.02 to 1.16; p=0.006). Conclusions Policymakers, clinicians and patients should be aware that lower quality guidelines, and those reporting conflicts of interest are more likely to promote vitamin D supplementation. Guideline organizations should improve the quality of their recommendations' development and the management of conflicts of interest. Users and editors should be aware of these findings when using and appraising guidelines. |
| Databáze: | OpenAIRE |
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