Successful Treatment of Nocardia nova Bacteremia and Multilobar Pneumonia With Clarithromycin in a Heart Transplant Patient
| Autor: | Meir Shinnar, Ronald S. Freudenberger, Monzarin Mahal, Sarjita D Naik, R Mateo-Bibeau |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Lung Diseases
Male medicine.medical_specialty medicine.medical_treatment Nocardia Infections Bacteremia Postoperative Complications Clarithromycin medicine Humans Aged Antibacterial agent Heart transplantation Transplantation biology business.industry Nocardia Pneumonia bacterial infections and mycoses medicine.disease biology.organism_classification Anti-Bacterial Agents Surgery Heart Transplantation business medicine.drug |
| Zdroj: | Transplantation Proceedings. 39:1720-1722 |
| ISSN: | 0041-1345 |
| Popis: | Nocardia is an opportunistic pathogen in solid organ transplantation for which long-term sulfonamide therapy is considered the treatment of choice. We report a patient 7 months status post-orthotopic heart transplantation with Nocardia nova bacteremia and pneumonia. Initial treatment consisted of intravenous trimethoprim-sulfamethoxazole, which cleared blood cultures, but the patient subsequently went into renal failure and required alternative therapy. This report describes the first case of N nova bacteremia after orthotopic heart transplantation successfully treated with clarithromycin. All therapy should be guided by antibiotic sensitivity, and combination therapy should be considered in acutely ill patients and cases where in vitro synergy has been documented. This case suggests that clarithromycin can be an alternative treatment in cases of sulfonamide resistance, intolerance, or allergy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect