Exploiting the Fruitfly, Drosophila melanogaster, to Identify the Molecular Basis of Cryptochrome-Dependent Magnetosensitivity
| Autor: | Anna L. Munro, Adam A Bradlaugh, Alex R. Jones, Richard A. Baines |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physics and Astronomy (miscellaneous) biology FAD magnetic field Astronomy and Astrophysics Statistical and Nonlinear Physics Computational biology biology.organism_classification animal magnetoreception neuron lcsh:QC1-999 Atomic and Molecular Physics and Optics 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cryptochrome Genetic model insect cryptochrome Drosophila melanogaster Drosophila lcsh:Physics 030217 neurology & neurosurgery |
| Zdroj: | Quantum Reports, Vol 3, Iss 7, Pp 127-136 (2021) |
| ISSN: | 2624-960X |
| Popis: | The flavoprotein CRYPTOCHROME (CRY) is now generally believed to be a magnetosensor, providing geomagnetic information via a quantum effect on a light-initiated radical pair reaction. Whilst there is considerable physical and behavioural data to support this view, the precise molecular basis of animal magnetosensitivity remains frustratingly unknown. A key reason for this is the difficulty in combining molecular and behavioural biological experiments with the sciences of magnetics and spin chemistry. In this review, we highlight work that has utilised the fruit fly, Drosophila melanogaster, which provides a highly tractable genetic model system that offers many advantages for the study of magnetosensitivity. Using this “living test-tube”, significant progress has been made in elucidating the molecular basis of CRY-dependent magnetosensitivity. |
| Databáze: | OpenAIRE |
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