Expression of microRNA‐21 and TIMP‐3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents
| Autor: | Esteban Daudén, Yolanda Delgado-Jiménez, Raquel Navarro, Mar Llamas-Velasco, Juan Guinea-Viniegra |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Necrosis Palmoplantar pustulosis Biopsy medicine.medical_treatment Dermatology Pathology and Forensic Medicine Pathogenesis Psoriasis microRNA Humans Medicine Prospective Studies Skin Tissue Inhibitor of Metalloproteinase-3 Tumor Necrosis Factor-alpha business.industry Adalimumab Middle Aged medicine.disease Infliximab MicroRNAs Cross-Sectional Studies Cytokine Case-Control Studies Immunology Female Tumor Necrosis Factor Inhibitors Tumor necrosis factor alpha medicine.symptom business Guttate psoriasis |
| Zdroj: | Journal of Cutaneous Pathology. 49:116-122 |
| ISSN: | 1600-0560 0303-6987 |
| Popis: | Background Expression of microRNA-21 (miR-21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP-3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFα) sheddase TACE (TNFα-converting enzyme)/ADAM17. We described the profile of miR-21 and TIMP-3 in paradoxical psoriasiform reactions induced by anti-TNFα drugs and in a control group to elucidate the pathogenesis of this reactions. Methods We performed an analytic, cross-sectional, prospective, experimental case-control study. We compared our findings with those of non-induced psoriasis. Results We included 15 patients with a change of morphology (plaque to guttate psoriasis) and 10 patients with induced psoriasis (six palmoplantar pustulosis and four plaque psoriasis). Consecutive patients with different subtypes of non-induced, non-systemically treated psoriasis were included as a control group. We found that most cases with guttate psoriasis and with induced plaque psoriasis cases showed high expression of TIMP-3 expression and decreased or poorly increased levels of miR-21. The expression pattern was not homogeneous in the cases of induced palmoplantar pustulosis. These profiles differ from those of non-induced psoriasis. Conclusion We conclude that various pro-inflammatory cytokine profiles are involved in the pathogenesis of paradoxical psoriasiform reactions and non-induced psoriasis. |
| Databáze: | OpenAIRE |
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