Experimental Sleep Restriction Facilitates Pain and Electrically Induced Cortical Responses
| Autor: | Monica Wigemyr, Ingri B. Hjelle, Leif A. Viken, Trond Sand, Li Hu, Dagfinn Matre, Kristian Bernhard Nilsen, Stein Knardahl |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pain Threshold Adolescent Experimental Sleep Restriction Facilitates Pain and Cortical Responses Pain Stimulus (physiology) Electroencephalography Young Adult Physiology (medical) Threshold of pain medicine Pressure Humans Habituation Habituation Psychophysiologic Muscle Skeletal Sleep restriction Pain Measurement Skin Cerebral Cortex Electroshock Cross-Over Studies medicine.diagnostic_test Somatosensory Cortex Crossover study Healthy Volunteers Sleep deprivation Anesthesia Sleep Deprivation Female Neurology (clinical) Self Report medicine.symptom Trapezius muscle Psychology |
| Zdroj: | Sleep. 38(10) |
| ISSN: | 1550-9109 |
| Popis: | Study objectives Sleep restriction (SR) has been hypothesized to sensitize the pain system. The current study determined whether experimental sleep restriction had an effect on experimentally induced pain and pain-elicited electroencephalographic (EEG) responses. Design A paired crossover study. Intervention Pain testing was performed after 2 nights of 50% SR and after 2 nights with habitual sleep (HS). Setting Laboratory experiment at research center. Participants Self-reported healthy volunteers (n = 21, age range: 18-31 y). Measurements and results Brief high-density electrical stimuli to the forearm skin produced pinprick-like pain. Subjective pain ratings increased after SR, but only in response to the highest stimulus intensity (P = 0.018). SR increased the magnitude of the pain-elicited EEG response analyzed in the time-frequency domain (P = 0.021). Habituation across blocks did not differ between HS and SR. Event-related desynchronization (ERD) was reduced after SR (P = 0.039). Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017). Conclusion Sleep restriction (SR) increased the sensitivity to pressure pain and to electrically induced pain of moderate, but not low, intensity. The increased electrical pain could not be explained by a difference in habituation. Increased response magnitude is possibly related to reduced processing within the somatosensory cortex after partial SR. |
| Databáze: | OpenAIRE |
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