A prospective cohort study to evaluate peridomestic infection as a determinant of dengue transmission: Protocol
| Autor: | Miguel Nakamura, René Santos, Susana Román, Rogelio Danis-Lozano, José Ramos-Castañeda, Jorge Argáez-Sosa, Jorge X. Velasco-Hernandez, Ruth Aralí Martínez-Vega, Fredi Alexander Diaz-Quijano, Mariana Irina González-Fernández |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Insecticides Time Factors Insect Control Dengue fever law.invention Dengue Study Protocol law Environmental health Epidemiology Peridomestic Dengue transmission Disease Transmission Infectious Medicine Transmission Humans Prospective Studies Prospective cohort study business.industry Incidence (epidemiology) lcsh:Public aspects of medicine Cohort Immunity Public Health Environmental and Occupational Health lcsh:RA1-1270 Models Theoretical medicine.disease Virology Transmission (mechanics) Research Design Seasons Biostatistics business |
| Zdroj: | BMC Public Health BMC Public Health, Vol 12, Iss 1, p 262 (2012) |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/1471-2458-12-262 |
| Popis: | Background Vector control programs, which have focused mainly on the patient house and peridomestic areas around dengue cases, have not produced the expected impact on transmission. This project will evaluate the assumption that the endemic/epidemic transmission of dengue begins around peridomestic vicinities of the primary cases. Its objective is to assess the relationship between symptomatic dengue case exposure and peridomestic infection incidence. Methods/Design A prospective cohort study will be conducted (in Tepalcingo and Axochiapan, in the state of Morelos, Mexico), using the state surveillance system for the detection of incident cases. Paired blood specimens will be collected from both the individuals who live with the incident cases and a sample of subjects residing within a 25-meter radius of such cases (exposed cohort), in order to measure dengue-specific antibodies. Other subjects will be selected from areas which have not presented any incident cases within 200 meters, during the two months preceding the sampling (non-exposed cohort). Symptomatic/asymptomatic incident infection will be considered as the dependent variable, exposure to confirmed dengue cases, as the principal variable, and the socio-demographic, environmental and socio-cultural conditions of the subjects, as additional explanatory variables. Discussion Results indicating a high infection rate among the exposed subjects would justify the application of peridomestic control measures and call for an evaluation of alternate causes for insufficient program impact. On the other hand, a low incidence of peridomestic-infected subjects would support the hypothesis that infection occurs outside the domicile, and would thus explain why the vector control measures applied in the past have exerted such a limited impact on cases incidence rates. The results of the present study may therefore serve to reassess site selection for interventions of this type. |
| Databáze: | OpenAIRE |
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