Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia
| Autor: | Liv S. Clasen, Stephen J. Gotts, Rebecca E. Watsky, Xueping Zhou, Anna E. Ordóñez, M Deanna, Peter Gochman, Siyuan Liu, Dede Greenstein, Rebecca A. Berman, Francois Lalonde, Lorie Shora, Alex Martin, Harrison McAdams, Judith L. Rapoport, Nitin Gogtay |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Sensory system Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Connectome medicine Humans In patient Childhood psychosis Age of Onset Biological Psychiatry Cerebral Cortex Resting state fMRI business.industry Siblings Functional connectivity medicine.disease Network connectivity Magnetic Resonance Imaging Sensorimotor Areas Psychiatry and Mental health 030104 developmental biology Endocrinology Schizophrenia Female Nerve Net business 030217 neurology & neurosurgery |
| Zdroj: | Schizophrenia Research. 197:219-225 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2018.01.003 |
| Popis: | Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients and their siblings exhibit similar abnormalities of functional connectivity.A whole-brain, data-driven approach was used to assess resting-state functional connectivity differences in COS (patients/siblings/controls, n: 26/28/33) and AOS (n: 19/28/30). There were no significant differences in age, sex, or head motion across groups in each dataset and as designed, the COS dataset has a significantly lower age than the AOS.Both COS and AOS patients showed decreased functional connectivity relative to controls among a wide set of brain regions (P0.05, corrected), but their siblings did not. Decreased connectivity in COS and AOS patients showed no amplitude differences and was not modulated by age-at-onset or medication doses. Cluster analysis revealed that these regions fell into two large-scale networks: one sensorimotor network and one centered on default-mode network regions, but including higher-order cognitive areas only in COS. Decreased connectivity between these two networks was notable (P0.05, corrected) for both patient groups.A shared pattern of attenuated functional connectivity was found in COS and AOS, supporting the continuity of childhood-onset and adult-onset schizophrenia. Connections were altered between sensorimotor areas and default-mode areas in both COS and AOS, suggesting potential abnormalities in processes of self-monitoring and sensory prediction. The absence of substantial dysconnectivity in siblings indicates that attenuation is state-related. |
| Databáze: | OpenAIRE |
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