Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

Autor: Lisa W. Martin, Tuomas O. Kilpeläinen, Xiuqing Guo, Kurt Lohman, Ching-Ti Liu, Jerome I. Rotter, Pirjo Komulainen, Lili Milani, Ilja M. Nolte, Yuri Milaneschi, Andres Metspalu, Yii-Der Ida Chen, Tõnu Esko, Jovia L. Nierenberg, Mika Kähönen, Marjan Ilkov, Dennis O. Mook-Kanamori, Karen Schwander, W. James Gauderman, Hanfei Xu, Vilmundur Gudnason, Alisa K. Manning, Gudny Eiriksdottir, David R. Hillman, Elise Lim, Hugues Aschard, John M. Starr, Michael R. Brown, Alanna C. Morrison, Eric Boerwinkle, Stefan Weiss, Maris Alver, Konstantin Strauch, Thomas Meitinger, Tuomo Rankinen, Timo A. Lakka, Harold Snieder, Stephen S. Rich, Yun Ju Sung, Diana van Heemst, Wanqing Wen, Marcus Dörr, Peter J. van der Most, Terho Lehtimäki, Nora Franceschini, Treva Rice, Amy R. Bentley, Dan E. Arking, Susan Redline, Nienke R. Biermasz, Sarah E. Harris, Melanie Waldenberger, Claude Bouchard, M. Arfan Ikram, Walter Palmas, Lynne E. Wagenknecht, Bruce M. Psaty, Daniel Levy, Cornelia M. van Duijn, Joshua C. Bis, Kelly A. Hall, José Eduardo Krieger, Tanika N. Kelly, Kari E. North, Brigitte Kühnel, Phyllis C. Zee, Melissa A. Richard, Lyle J. Palmer, Till Roenneberg, Alexandre C. Pereira, Yongmei Liu, Andrea R. V. R. Horimoto, Jie Yao, Han Chen, Jiang He, Pamela J. Schreiner, Patricia B. Munroe, Wei Zheng, Charles Kooperberg, Paul S. de Vries, Ana Barac, Rainer Rauramaa, Leo-Pekka Lyytikäinen, James M. Shikany, Brian E. Cade, Christian Gieger, Stephen Sidney, Alan B. Zonderman, Tamar Sofer, Chuan Gao, Thomas W. Winkler, Xiao-Ou Shu, Ian J. Deary, Uwe Völker, RJ Waken, Heming Wang, Myriam Fornage, Brenda W.J.H. Penninx, Gregory P. Wilson, Dina Vojinovic, Robert B. Wallace, Kenneth Rice, Ervin R. Fox, Jeffrey R. O'Connell, Annemarie I. Luik, Traci M. Bartz, Xiaofeng Zhu, Najaf Amin, Nicholette D. Palmer, Sami Heikkinen, Kumaraswamynaidu Chitrala, Raymond Noordam, Jiwon Lee, André G. Uitterlinden, Sutapa Mukherjee, Hans J. Grabe, Mario Sims, Sina A. Gharib, Daniel J. Gottlieb, Dabeeru C. Rao, Annette Peters, Reedik Mägi, Solomon K. Musani, Michele K. Evans, Lenore J. Launer
Přispěvatelé: Harvard Medical School [Boston] (HMS), Broad Institute [Cambridge], Harvard University-Massachusetts Institute of Technology (MIT), Hallym University, Department of Educational Psychology and Counseling, National Taiwan Normal University (NTNU), Département de Biologie Computationnelle - Department of Computational Biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Leiden University Medical Center (LUMC), Universiteit Leiden, This project was supported by the US National Heart, Lung, and Blood Institute (NHLBI) R01HL118305. HW and SR were supported by NHLBI R35HL135818. BEC was supported by NHLBI K01HL135405. ARB was supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). D.v.H. was supported by the European Commission funded project HUMAN (Health-2013-INNOVATION-1-602757). The CHARGE cohorts were supported in part by NHLBI infrastructure grant HL105756. Study-specific acknowledgments can be found in the Supplementary Notes., European Project: 602757,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,HUMAN(2013), Life Course Epidemiology (LCE), Epidemiology, Radiology & Nuclear Medicine, Internal Medicine, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Digital Health, Massachusetts Institute of Technology (MIT)-Harvard University [Cambridge], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine
Rok vydání: 2020
Předmět:
0301 basic medicine
Mean arterial pressure
Diastole
Blood Pressure
Biology
3121 Internal medicine
Genome
Polymorphism
Single Nucleotide
Elevated blood
3124 Neurology and psychiatry
Article
Cellular and Molecular Neuroscience
03 medical and health sciences
TRPC3
0302 clinical medicine
SDG 3 - Good Health and Well-being
Humans
Molecular Biology
Gene
030304 developmental biology
Genetics
0303 health sciences
[STAT.AP]Statistics [stat]/Applications [stat.AP]
Short sleep
Sleep in non-human animals
Pulse pressure
Psychiatry and Mental health
030104 developmental biology
Blood pressure
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Genetic Loci
Hypertension
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
3111 Biomedicine
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
Sleep
[STAT.ME]Statistics [stat]/Methodology [stat.ME]
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: Mol Psychiatry
Molecular Psychiatry, 26(11), 6293-6304. SPRINGERNATURE
Molecular Psychiatry
Molecular Psychiatry, 2021, 26 (11), pp.6293-6304. ⟨10.1038/s41380-021-01087-0⟩
Molecular Psychiatry. Nature Publishing Group
Wang, H, Noordam, R, Cade, B E, Schwander, K, Winkler, T W, Lee, J, Sung, Y J, Bentley, A R, Manning, A K, Aschard, H, Kilpeläinen, T O, Ilkov, M, Brown, M R, Horimoto, A R, Richard, M, Bartz, T M, Vojinovic, D, Lim, E, Nierenberg, J L, Liu, Y, Chitrala, K, Rankinen, T, Musani, S K, Franceschini, N, Rauramaa, R, Alver, M, Zee, P C, Harris, S E, van der Most, P J, Nolte, I M, Munroe, P B, Palmer, N D, Kühnel, B, Weiss, S, Wen, W, Hall, K A, Lyytikäinen, L-P, O'Connell, J, Eiriksdottir, G, Launer, L J, de Vries, P S, Arking, D E, Chen, H, Boerwinkle, E, Krieger, J E, Schreiner, P J, Sidney, S, Shikany, J M, Rice, K, Chen, Y-D I, Gharib, S A, Bis, J C, Luik, A I, Ikram, M A, Uitterlinden, A G, Amin, N, Xu, H, Levy, D, He, J, Lohman, K K, Zonderman, A B, Rice, T K, Sims, M, Wilson, G, Sofer, T, Rich, S S, Palmas, W, Yao, J, Guo, X, Rotter, J I, Biermasz, N R, Mook-Kanamori, D O, Martin, L W, Barac, A, Wallace, R B, Gottlieb, D J, Komulainen, P, Heikkinen, S, Mägi, R, Milani, L, Metspalu, A, Starr, J M, Milaneschi, Y, Waken, R J, Gao, C, Waldenberger, M, Peters, A, Strauch, K, Meitinger, T, Roenneberg, T, Völker, U, Dörr, M, Shu, X-O, Mukherjee, S, Hillman, D R, Kähönen, M, Wagenknecht, L E, Gieger, C, Grabe, H J, Zheng, W, Palmer, L J, Lehtimäki, T, Gudnason, V, Morrison, A C, Pereira, A C, Fornage, M, Psaty, B M, van Duijn, C M, Liu, C-T, Kelly, T N, Evans, M K, Bouchard, C, Fox, E R, Kooperberg, C, Zhu, X, Lakka, T A, Esko, T, North, K E, Deary, I J, Snieder, H, Penninx, B W J H, Gauderman, W J, Rao, D C, Redline, S & van Heemst, D 2021, ' Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure ', Molecular Psychiatry . https://doi.org/10.1038/s41380-021-01087-0
Molecular Psychiatry, 26(11), 6293-6304. Nature Publishing Group
Wang, H, Noordam, R, Cade, B E, Schwander, K, Winkler, T W, Lee, J, Sung, Y J, Bentley, A R, Manning, A K, Aschard, H, Kilpeläinen, T O, Ilkov, M, Brown, M R, Horimoto, A R, Richard, M, Bartz, T M, Vojinovic, D, Lim, E, Nierenberg, J L, Liu, Y, Chitrala, K, Rankinen, T, Musani, S K, Franceschini, N, Rauramaa, R, Alver, M, Zee, P C, Harris, S E, van der Most, P J, Nolte, I M, Munroe, P B, Palmer, N D, Kühnel, B, Weiss, S, Wen, W, Hall, K A, Lyytikäinen, L-P, O'Connell, J, Eiriksdottir, G, Launer, L J, de Vries, P S, Arking, D E, Chen, H, Boerwinkle, E, Krieger, J E, Schreiner, P J, Sidney, S, Shikany, J M, Rice, K, Chen, Y-D I, Gharib, S A, Bis, J C, Luik, A I, Ikram, M A, Uitterlinden, A G, Amin, N, Xu, H, Levy, D, He, J, Lohman, K K, Zonderman, A B, Rice, T K, Sims, M, Wilson, G, Sofer, T, Rich, S S, Palmas, W, Yao, J, Guo, X, Rotter, J I, Biermasz, N R, Mook-Kanamori, D O, Martin, L W, Barac, A, Wallace, R B, Gottlieb, D J, Komulainen, P, Heikkinen, S, Mägi, R, Milani, L, Metspalu, A, Starr, J M, Milaneschi, Y, Waken, R J, Gao, C, Waldenberger, M, Peters, A, Strauch, K, Meitinger, T, Roenneberg, T, Völker, U, Dörr, M, Shu, X-O, Mukherjee, S, Hillman, D R, Kähönen, M, Wagenknecht, L E, Gieger, C, Grabe, H J, Zheng, W, Palmer, L J, Lehtimäki, T, Gudnason, V, Morrison, A C, Pereira, A C, Fornage, M, Psaty, B M, van Duijn, C M, Liu, C-T, Kelly, T N, Evans, M K, Bouchard, C, Fox, E R, Kooperberg, C, Zhu, X, Lakka, T A, Esko, T, North, K E, Deary, I J, Snieder, H, Penninx, B W J H, Gauderman, W J, Rao, D C, Redline, S & van Heemst, D 2021, ' Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure ', Molecular Psychiatry, vol. 26, pp. 6293-6304 . https://doi.org/10.1038/s41380-021-01087-0
Molecular Psychiatry, Nature Publishing Group, In press, ⟨10.1038/s41380-021-01087-0⟩
Wang, H, Noordam, R, Cade, B E, Schwander, K, Winkler, T W, Lee, J, Sung, Y J, Bentley, A R, Manning, A K, Aschard, H, Kilpeläinen, T O, Ilkov, M, Brown, M R, Horimoto, A R, Richard, M, Bartz, T M, Vojinovic, D, Lim, E, Nierenberg, J L, Liu, Y, Chitrala, K, Rankinen, T, Musani, S K, Franceschini, N, Rauramaa, R, Alver, M, Zee, P C, Harris, S E, van der Most, P J, Nolte, I M, Munroe, P B, Palmer, N D, Kühnel, B, Weiss, S, Wen, W, Hall, K A, Lyytikäinen, L-P, O’Connell, J, Eiriksdottir, G, Launer, L J, de Vries, P S, Arking, D E, Chen, H, Boerwinkle, E, Krieger, J E, Schreiner, P J, Sidney, S, Shikany, J M, Rice, K, Chen, Y-D I, Gharib, S A, Bis, J C, Luik, A I, Ikram, M A, Uitterlinden, A G, Amin, N, Xu, H, Levy, D, He, J, Lohman, K K, Zonderman, A B, Rice, T K, Sims, M, Wilson, G, Sofer, T, Rich, S S, Palmas, W, Yao, J, Guo, X, Rotter, J I, Biermasz, N R, Mook-Kanamori, D O, Martin, L W, Barac, A, Wallace, R B, Gottlieb, D J, Komulainen, P, Heikkinen, S, Mägi, R, Milani, L, Metspalu, A, Starr, J M, Milaneschi, Y, Waken, R J, Gao, C, Waldenberger, M, Peters, A, Strauch, K, Meitinger, T, Roenneberg, T, Völker, U, Dörr, M, Shu, X-O, Mukherjee, S, Hillman, D R, Kähönen, M, Wagenknecht, L E, Gieger, C, Grabe, H J, Zheng, W, Palmer, L J, Lehtimäki, T, Gudnason, V, Morrison, A C, Pereira, A C, Fornage, M, Psaty, B M, van Duijn, C M, Liu, C-T, Kelly, T N, Evans, M K, Bouchard, C, Fox, E R, Kooperberg, C, Zhu, X, Lakka, T A, Esko, T N, North, K E, Deary, I J, Snieder, H, Penninx, B W J H, Gauderman, W J, Rao, D C, Redline, S & van Heemst, D 2021, ' Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure ', Molecular Psychiatry, vol. 26, no. 11, pp. 6293-6304 . https://doi.org/10.1038/s41380-021-01087-0
ISSN: 1476-5578
1359-4184
Popis: Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups using 1 degree of freedom (1df) interaction and 2df joint tests. Primary multi-ancestry analyses in 62,969 individuals in stage 1 identified 3 novel loci that were replicated in an additional 59,296 individuals in stage 2, including rs7955964 (FIGNL2/ANKRD33) showing significant 1df interactions with long sleep duration and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) showing significant 1df interactions with short sleep duration (Pint < 5×10−8). Secondary ancestry-specific two-stage analyses and combined stage 1 and 2 analyses additionally identified 23 novel loci that need external replication, including 3 and 5 loci showing significant 1df interactions with long and short sleep duration, respectively (Pint < 5×10−8). Multiple genes mapped to our 26 novel loci have known functions in sleep-wake regulation, nervous and cardiometabolic systems. We also identified new gene by long sleep interactions near five known BP loci (≤1Mb) including NME7, FAM208A, MKLN1, CEP164, and RGL3/ELAVL3 (Pint < 5×10−8). This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
Databáze: OpenAIRE
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