Impaired IgG Production in the Lungs of HIV-Infected Individuals
| Autor: | Linda K. Bowen, Kathleen M. Heidler, Blake A. Spain, David S. Wilkes, Homer L. Twigg, Diaa M. Soliman |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.diagnostic_test biology Immunology HIV Infections Peripheral blood mononuclear cell Pulmonary Alveoli Antibody production Bronchoalveolar lavage medicine.anatomical_structure Transforming Growth Factor beta Immunoglobulin G Hiv infected medicine biology.protein Humans Female Secretion Antibody Bronchoalveolar Lavage Fluid Transforming growth factor Respiratory tract |
| Zdroj: | Cellular Immunology. 170:127-133 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.1996.0142 |
| Popis: | Human immunodeficiency virus (HIV)-infected individuals are at risk for pulmonary infections with encapsulated bacterial pathogens. This could reflect impaired production of opsonizing antibodies in the lower respiratory tract. We examined antibody production in the alveolar space by measuring immunoglobulin concentrations in bronchoalveolar lavage (BAL) of HIV-infected patients and normal volunteers and by assessing the ability of alveolar macrophages (AM) to induce immunoglobulin production in normal peripheral blood mononuclear cells (PBMC). BAL from HIV-infected patients contained significantly less IgG than normal BAL. IgA and IgM concentrations were similar in both groups. Normal AM supported IgG and IgA production in PBMC. While HIV AM could induce IgA production in PBMC, in no instance did they induce IgG secretion. HIV AM produced significantly more transforming growth factor-beta (TGF-beta), a factor known to suppress IgG production, than normal AM. Finally, TGF-beta antibodies blocked the inhibitory effect of HIV AM on normal IgG secretion without affecting IgA secretion. These findings demonstrate impaired production of opsonizing IgG in the alveolar space of HIV-infected subjects and implicate excess TGF-beta production by AM as the cause of this impairment. |
| Databáze: | OpenAIRE |
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