The effects of long-term exposure to disease-modifying drugs during pregnancy in multiple sclerosis
| Autor: | Paulo Diniz da Gama, Adriana Tarulla, Joseph Bruno Bidin Brooks, Adriana Aguayo, Rogerio Rizo Morales, Mike Boggild, Regina Maria Papais Alvarenga, Claudia Cristina Ferreira Vasconcelos, Giselle Lourenço, Marcus Goncalves, Damacio Ramón Kaimen-Maciel, Cristiane Borges Patroclo, Sandra Maria Garcia de Almeida, Kirsty Deborah Schaerer, Anderson Kuntz Grzesiuk, Sonia Beatriz Felix Ribeiro, Patricia Onaha, Maria Lucia Brito Ferreira, Adriana Carrá, Alessandro Finkelsztejn, Maria Cristina Brandao Giacomo, Soniza Vieira Alves-Leon, Josiane Lopes, Miguel Ángel Macías-Islas, Elizabeth Regina Comini-Frota, Andre Serafin Gallina, Walter Oleschko Arruda, Sidney Gomes, Fabiola Rachid Malfetano, Marcos Papais Alvarenga, Taysa Alexandrino Gonsalves Jube Ribeiro, Sergio Georgetto, Heidi Johanna Salminen, Juliana Finkelsztejn, Marcos Seefeld, Patricia Santoro, Lucas Dias de Freitas, Yara Dadalti Fragoso, Nívea de Macedo Oliveira Morales, Paula Vallegas Soares, Celso Luis Silva Oliveira |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Multiple Sclerosis Databases Factual Argentina Disease Infant Newborn Diseases Central nervous system disease Pregnancy Recurrence medicine Humans Immunologic Factors Glatiramer acetate Mexico Retrospective Studies Cesarean Section business.industry Multiple sclerosis Infant Newborn Retrospective cohort study Glatiramer Acetate General Medicine Delivery Obstetric medicine.disease United Kingdom Obstetric Labor Complications Obstetric labor complication Surgery Pregnancy Complications Breast Feeding Disease Progression Female Interferons Neurology (clinical) Peptides business Breast feeding Brazil medicine.drug |
| Zdroj: | Clinical Neurology and Neurosurgery. 115:154-159 |
| ISSN: | 0303-8467 |
| Popis: | Background and objective Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT for MS on pregnancy and on disease course. Patients and methods Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis. Results From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers’ post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment. Conclusion It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised. |
| Databáze: | OpenAIRE |
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