Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns
| Autor: | Sara Manti, Giovanna Cardile, Mamì C, Gabriella D'Angelo, Lucia Marseglia, Vincenzo Salpietro, Elisa Giaimo, Antonio Gennaro Nicotera, Daniela Caccamo, Maria Bonsignore, Gabriella Di Rosa, Angela Alibrandi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Hyperhomocysteinemia medicine.medical_specialty Pediatrics Article Subject Genotype Population Biochemistry Gastroenterology Cohort Studies Pregnancy Risk Factors Internal medicine Prenatal Diagnosis medicine Odds Ratio Humans lcsh:QH573-671 education Methylenetetrahydrofolate Reductase (NADPH2) Full Term Demography education.field_of_study Polymorphism Genetic biology Neonatal encephalopathy business.industry lcsh:Cytology Infant Newborn Cell Biology General Medicine medicine.disease Echoencephalography White Matter Premature birth Methylenetetrahydrofolate reductase biology.protein Linear Models Premature Birth Apgar score Female business Hyperhomocysteinemia MTHFR polymorphisms late preterm infants term infants Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2015 (2015) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born (P<0.014), lower GA(P<0.000), lower Apgar score at 1 minutes(P<0.000)and 5 minutes(P<0.000), and 1298AC and 677CT/1298AC genotypes (P<0.000andP<0.000). In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA. The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling. |
| Databáze: | OpenAIRE |
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