An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer
| Autor: | Giorgio Guazzoni, Amelia Cimmino, Ettore De Berardinis, Nicolae Crisan, Gabriele Cozzi, Gilberto L. Almeida, Deliu Victor Matei, Matteo Muto, Antonio Cioffi, Riccardo Schiavina, Marco Borghesi, Giorgio Ivan Russo, Vincenzo Serretta, Savino M. Di Stasi, Pierluigi Bove, Shahrokh F. Shariat, Abdal Rahman Abu Farhan, Estevão Lima, Mihai Dorin Vartolomei, Michele Battaglia, Giovanni Grimaldi, Gennaro Musi, Vincenzo Mirone, Daniela Terracciano, Giuseppe Morgia, Francesco Cantiello, Giuseppe Lucarelli, Ottavio De Cobelli, Rocco Damiano, Rodolfo Hurle, Paolo Verze, Matteo Ferro, Sisto Perdonà, Gian Maria Busetto, Riccardo Autorino |
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| Přispěvatelé: | Ferro, Matteo, Vartolomei, Mihai Dorin, Russo, Giorgio Ivan, Cantiello, Francesco, Farhan, Abdal Rahman Abu, Terracciano, Daniela, Cimmino, Amelia, Di Stasi, Savino, Musi, Gennaro, Hurle, Rodolfo, Serretta, Vincenzo, Busetto, Gian Maria, De Berardinis, Ettore, Cioffi, Antonio, Perdonà, Sisto, Borghesi, Marco, Schiavina, Riccardo, Cozzi, Gabriele, Almeida, Gilberto L, Bove, Pierluigi, Lima, Estevao, Grimaldi, Giovanni, Matei, Deliu Victor, Crisan, Nicolae, Muto, Matteo, Verze, Paolo, Battaglia, Michele, Guazzoni, Giorgio, Autorino, Riccardo, Morgia, Giuseppe, Damiano, Rocco, de Cobelli, Ottavio, Shariat, Shahrokh, Mirone, Vincenzo, Lucarelli, Giuseppe, [et al.], Universidade do Minho, de Berardinis, Ettore, Almeida, Gilberto L., Ferro M, Vartolomei MD, Russo GI, Cantiello F, Farhan ARA, Terracciano D, Cimmino A, Di Stasi S, Musi G, Hurle R, Serretta V, Busetto GM, De Berardinis E, Cioffi A, Perdonà S, Borghesi M, Schiavina R, Cozzi G, Almeida GL, Bove P, Lima E, Grimaldi G, Matei DV,18, Crisan N, Muto M, Verze P, Battaglia M, Guazzoni G, Autorino R, Morgia G, Damiano R, de Cobelli O, Shariat S, Mirone V, Lucarelli G. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_treatment Prognosis 030232 urology & nephrology Comorbidity Gastroenterology Settore MED/24 - Urologia 0302 clinical medicine Bladder cancer Body mass index Obesity Medicine Aged 80 and over Hazard ratio Cystoscopy Middle Aged Tumor Burden Administration Intravesical Editorial Transitional cell carcinoma Chemotherapy Adjuvant 030220 oncology & carcinogenesis BCG Vaccine Disease Progression Female medicine.medical_specialty Prognosi Urology Cystectomy Disease-Free Survival 03 medical and health sciences Adjuvants Immunologic Internal medicine Humans Mortality Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Cancer staging Carcinoma Transitional Cell Science & Technology business.industry Proportional hazards model medicine.disease Urinary Bladder Neoplasms Concomitant Multivariate Analysis business |
| Zdroj: | World journal of urology (Internet) (2018): 1–8. doi:10.1007/s00345-018-2397-1 info:cnr-pdr/source/autori:Ferro M.; Vartolomei M.D.; Russo G.I.; Cantiello F.; Farhan A.R.A.; Terracciano D.; Cimmino A.; Di Stasi S.; Musi G.; Hurle R.; Serretta V.; Busetto G.M.; de Berardinis E.; Cioffi A.; Perdona S.; Borghesi M.; Schiavina R.; Cozzi G.; Almeida G.L.; Bove P.; Lima E.; Grimaldi G.; Matei D.V.; Crisan N.; Muto M.; Verze P.; Battaglia M.; Guazzoni G.; Autorino R.; Morgia G.; Damiano R.; de Cobelli O.; Shariat S.; Mirone V.; Lucarelli G./titolo:An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer/doi:10.1007%2Fs00345-018-2397-1/rivista:World journal of urology (Internet)/anno:2018/pagina_da:1/pagina_a:8/intervallo_pagine:1–8/volume Translational Andrology and Urology Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| DOI: | 10.1007/s00345-018-2397-1 |
| Popis: | PURPOSE: The body mass index (BMI) may be associated with an increased incidence and aggressiveness of urological cancers. In this study, we aimed to evaluate the impact of the BMI on survival in patients with T1G3 non-muscle-invasive bladder cancer (NMIBC). METHODS: A total of 1155 T1G3 NMIBC patients from 13 academic institutions were retrospectively reviewed and patients administered adjuvant intravesical Bacillus Calmette-Guérin (BCG) immunotherapy with maintenance were included. Multivariable Cox regression analysis was performed to identify factors predictive of recurrence and progression. RESULTS: After re-TURBT, 288 patients (27.53%) showed residual high-grade NMIBC, while 867 (82.89%) were negative. During follow-up, 678 (64.82%) suffered recurrence, and 303 (30%) progression, 150 (14.34%) died of all causes, and 77 (7.36%) died of bladder cancer. At multivariate analysis, tumor size (hazard ratio [HR]:1.3; p = 0.001), and multifocality (HR:1.24; p = 0.004) were significantly associated with recurrence (c-index for the model:55.98). Overweight (HR: 4; p M.D.V is supported by the Scholarship Foundation of the Republic of Austria—OeAD and by the EUSP Scholarship— European Association of Urology info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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