Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1
| Autor: | Navin Ramdhani, Frank J P M Huygen, Freek J. Zijlstra, Jan Klein, Albert W. Van Toorenenbergen |
|---|---|
| Přispěvatelé: | Anesthesiology, Clinical Chemistry |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Immunology Inflammation Tryptase Proinflammatory cytokine Pathogenesis Blister medicine Immunology and Allergy Humans Mast Cells Interleukin 6 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Serine Endopeptidases Middle Aged Mast cell medicine.disease Reflex Sympathetic Dystrophy medicine.anatomical_structure Complex regional pain syndrome biology.protein Tumor necrosis factor alpha Female Tryptases medicine.symptom business |
| Zdroj: | European Journal of Applied Physiology, 91, 516-524. Springer-Verlag |
| ISSN: | 1439-6319 |
| Popis: | The Complex Regional Pain Syndrome type 1 (CRPS1) is a complication of surgery or trauma but spontaneous development is also described. Although the pathogenesis remains debatable, afferent, efferent and central nervous system mechanisms are proposed. Recently we showed involvement of the proinflammatory cytokines IL-6 and TNFalpha which is direct evidence for an inflammatory process. Many types of cells, such as activated T lymphocytes, monocytes, macrophages and skin resident cells like mast cells, could contribute to the production of cytokines. Involvement of mast cells is relatively easy to detect by measurement of tryptase.To establish whether mast cells are involved in the inflammatory reactions during CRPS1.Twenty patients fulfilling the Bruehl criteria with CRPS1 in one extremity were studied. Impairment was assessed by registration of pain and measurement of differences in temperature, volume and mobility between the involved and uninvolved extremity. Blisters were made with a suction method in order to determine cytokines and mast cell derived tryptase in the involved and uninvolved extremity.In the blister fluid a significant difference (median +/- interquartile range, Wilcoxon signed-ranks test P0.05) was found between the involved and uninvolved extremity in IL-6 [53.5 (17.3-225) versus 6.2 (2-20.3) pg/ml], TNFalpha [31 (15.5-131.5) versus 8 (4-39) pg/ml], and tryptase [37 (20.5-62.3) versus 12.5 (6.7-23.5) ng/ml]. There was a significant correlation (0.455) between the intensity of pain and tryptase levels in the involved extremity (Spearman's test, P0.05).Mast cells are involved in inflammatory reactions during the CRPS1. Mast cells could play a role in the production of cytokines such as TNFalpha. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink