Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study
| Autor: | Lars Kristian Munck, Matilde Winther-Jensen, Tine Jess, Nynne Nyboe Andersen, Signe Wildt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Denmark Colitis Collagenous Population Gastroenterology Coeliac disease Autoimmune Diseases Microscopic colitis Internal medicine Humans Medicine Pharmacology (medical) education Autoimmune disease education.field_of_study Hepatology Collagenous colitis business.industry Odds ratio medicine.disease Comorbidity Ulcerative colitis Colitis Microscopic Case-Control Studies business |
| Zdroj: | Wildt, S, Munck, L K, Winther-Jensen, M, Jess, T & Nyboe Andersen, N 2021, ' Autoimmune diseases in microscopic colitis : A Danish nationwide case–control study ', Alimentary Pharmacology & Therapeutics, vol. 54, no. 11-12, pp. 1454-1462 . https://doi.org/10.1111/apt.16614 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/apt.16614 |
| Popis: | Background: The association between autoimmune diseases and microscopic colitis remains uncertain. Aims: To describe the association between autoimmune diseases and microscopic colitis by using a matched case–control design based on nationwide registry data. Methods: All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of autoimmune diseases were compared between cases with microscopic colitis and sex- and age-matched controls from the background population in a 1:10 ratio and evaluated by logistic regression calculating odds ratios (OR) with 95% confidence intervals (CI) adjusted for comorbidity. Analyses were stratified according to sex, age and the subtypes of lymphocytic and collagenous colitis. Results: We identified 15 597 cases with microscopic colitis and matched to 155 910 controls. In total, 3491 (22%) of patients with microscopic colitis had concomitant autoimmune disease compared to 16 521 (11%) of controls (OR, 2.46; 95% CI, 2.36-2.56). Adjusting for comorbidities reduced the OR to 2.09 (95% CI, 2.01-2.19). Analyses showed increased ORs with 16 different autoimmune diseases, particularly of gastrointestinal and endocrine origin, and connective tissue disorders. The highest ORs were for coeliac disease (OR = 10.15; 95% CI, 8.20-12.6), Crohn’s disease (OR = 2.47; 95% CI, 2.10-2.91) and ulcerative colitis (OR = 6.73; 95% CI, 6.20-7.30). In stratified analyses younger age at diagnosis and collagenous colitis were associated with higher odds. Conclusion: Using nationwide registry data, microscopic colitis was associated with a wide range of autoimmune diseases, especially of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|