An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9

Autor: Liang Sun, Panpan Lu, Yujia Xia, Qiang Ding, Shuping Ding, Mei Liu
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Chemokine
MMP2
Apoptosis
MMP9
CD133+ liver cancer cells
CXCR3
Chemokine CXCL9
Metastasis
Mice
0302 clinical medicine
Cell Movement
immune system diseases
Tumor Cells
Cultured
Tumor Microenvironment
Medicine
AC133 Antigen
skin and connective tissue diseases
biology
Liver Neoplasms
Middle Aged
Prognosis
adhesion
Matrix Metalloproteinase 9
Oncology
030220 oncology & carcinogenesis
CXCR3/CXCL9
Matrix Metalloproteinase 2
CXCL9
Female
Liver cancer
Research Paper
Carcinoma
Hepatocellular
Receptors
CXCR3
Interferon-gamma
03 medical and health sciences
stomatognathic system
Biomarkers
Tumor
Animals
Humans
metastasis
Neoplasm Invasiveness
Cell Proliferation
Neoplasm Staging
Tumor microenvironment
business.industry
medicine.disease
Xenograft Model Antitumor Assays
Alternative Splicing
stomatognathic diseases
030104 developmental biology
Cancer research
biology.protein
business
Follow-Up Studies
Zdroj: Oncotarget
ISSN: 1949-2553
Popis: Metastasis of liver cancer is closely linked to tumor microenvironment, in which chemokines and their receptors act in an important role. The CXCR3, the receptor of chemokine CXCL9, belongs to a superfamily of rhodopsin-like seven transmembrane GPCRs and CXCR subfamily. In HCC tissues, CXCR3 was frequently upregulated and correlated with tumor size, tumor differentiation, portal invasion and metastasis. In the study, CXCR3-A isoform that was bound by CXCL9 was found to cause significant change of ERK1/2 phosphorylation level in the MAPK signaling pathway, consequently upregulating the MMP2 and MMP9 expression and promoting invasion and metastasis of CD133+ liver cancer cells. Also, CXCR3-A suppressed the adhesion ability of CD133+ liver cancer cells that stimulated by CXCL9 for 24h. These findings suggest that CXCR3 and its ligand CXCL9 could promote the metastasis of liver cancer cells and might be a potential target for the intervention of liver cancer metastasis.
Databáze: OpenAIRE
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