Beneficial effects of isometric strength training on endothelial dysfunction in rats
| Autor: | Vincent Gaume, H. Figard, Alain Berthelot, Céline Demougeot, Fabienne Mougin |
|---|---|
| Přispěvatelé: | Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Physiology
Endocrinology Diabetes and Metabolism Indomethacin Aorta Thoracic Vasodilation Isometric exercise MESH: Physical Conditioning Animal MESH: Rats Sprague-Dawley 030204 cardiovascular system & hematology MESH: Estrogens Rats Sprague-Dawley chemistry.chemical_compound 0302 clinical medicine MESH: NG-Nitroarginine Methyl Ester MESH: Animals MESH: Isometric Contraction Enzyme Inhibitors Endothelial dysfunction 0303 health sciences MESH: Indomethacin Nutrition and Dietetics Estradiol Cumulative dose General Medicine Iberiotoxin [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences NG-Nitroarginine Methyl Ester medicine.anatomical_structure MESH: Enzyme Inhibitors Ovariectomized rat Female MESH: Nitric Oxide Synthase MESH: Endothelium Vascular MESH: Estradiol medicine.medical_specialty Endothelium MESH: Rats Ovariectomy MESH: Aorta Thoracic Physical Exertion MESH: Prostaglandin-Endoperoxide Synthases MESH: Ovariectomy Calcium-Transporting ATPases Nitric Oxide Apamin MESH: Calcium-Transporting ATPases MESH: Physical Exertion MESH: Vasodilation 03 medical and health sciences MESH: Cyclooxygenase Inhibitors Isometric Contraction Physical Conditioning Animal Physiology (medical) Internal medicine medicine Animals Cyclooxygenase Inhibitors 030304 developmental biology business.industry MESH: Acetylcholine Estrogens medicine.disease Acetylcholine Rats Endocrinology chemistry Prostaglandin-Endoperoxide Synthases MESH: Nitric Oxide Endothelium Vascular Nitric Oxide Synthase business MESH: Female |
| Zdroj: | Applied Physiology, Nutrition, and Metabolism Applied Physiology, Nutrition, and Metabolism, NRC Research Press (Canadian Science Publishing), 2006, 31 (5), pp.621-30. ⟨10.1139/h06-070⟩ |
| ISSN: | 1715-5312 1715-5320 |
| Popis: | Using female 4-week-old Sprague–Dawley rats, we investigated the effects of 14 weeks of progressive strength isometric training on endothelium dysfunction after estrogen deficiency. We also proposed possible mechanism(s) by which such training acted on endothelium-dependent vasodilation in thoracic aortic rings. Rats were randomly divided into 4 groups of 8 rats: a sham operated group, an ovariectomized sedentary group receiving 17β-estradiol vehicle s.c. daily, an ovariectomized sedentary group receiving a daily injection of 20 µg·kg–1 17β-estradiol s.c., and an ovariectomized exercised group receiving daily s.c. vehicle. Vascular reactivity of aortic rings have been evaluated by a cumulative dose of acetylcholine (ACh), in the presence or absence of l-NAME (N-nitro-l-arginine methyl ester), indomethacin, thapsigargin, iberiotoxin, apamin, and tetraethylammonium. Ovariectomy markedly decreased the relaxation caused by ACh, whereas 17β-estradiol treatment induced a significant increase in the relaxation elicited by ACh. Isometric exercise enhanced relaxation due to ACh. This enhancement was attenuated in the presence of l-NAME, indomethacin, thapsigargin, iberiotoxin, and apamin. Our data indicated, for the first time, that the endothelium-dependent relaxant response to ACh was markedly improved in trained ovariectomized rats. This increased vasodilation is mediated by nitric oxide, cyclooxygenase, sarco-endoplasmic reticulum Ca2+-ATPase pathways, and endothelium-derived hyperpolarizing factor. Finally, this study suggested that resistance training may provide benefits in addressing vascular dysfunction consequent to a decline in estrogen levels after menopause. However, any benefits for age-related vascular dysfunction remain to be demonstrated. |
| Databáze: | OpenAIRE |
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