Oxygenated Hexylitaconates from a Marine Sponge-Derived Fungus Penicillium sp
| Autor: | Eun Sook Yoo, Jee H. Jung, Yoon Mi Lee, Jongki Hong, Ping Zhang, Kyung Sook Bae, Jian Lin Li |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Metabolite Interleukin-1beta Anti-Inflammatory Agents Molecular Conformation Nitric Oxide Nitric oxide Microbiology Mice chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans Apiospora Cytotoxicity chemistry.chemical_classification biology Interleukin-6 Tumor Necrosis Factor-alpha Macrophages Aspergillus niger Penicillium Succinates General Chemistry General Medicine biology.organism_classification Porifera Oxygen Dicarboxylic acid Penicillium striatisporum chemistry |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 59:120-123 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of Aspergillus niger, Penicillium striatisporum, or Apiospora montagnei. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds 1 and 4 showed weak inhibition of IL-1β production at the concentration of 200 µM. |
| Databáze: | OpenAIRE |
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