EVALUATION OF INDOCYANINE GREEN RETENTION AND AMINOPYRINE BREATH TESTS IN PATIENTS WITH MALIGNANT BILIARY OBSTRUCTION
| Autor: | K. W. Tam Yu, Chung Mao Lo, Edward C. S. Lai, Q. S. Wang, ST Fan, Jason W. H. Wong |
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| Rok vydání: | 1994 |
| Předmět: |
Indocyanine Green
Male medicine.medical_specialty Malignancy Gastroenterology chemistry.chemical_compound Liver Function Tests Internal medicine medicine Humans Postoperative outcome In patient Postoperative Period Aminopyrine Aged Aged 80 and over Breath test Prothrombin time Cholestasis medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Surgery Treatment Outcome Breath Tests chemistry Female Obstructive jaundice High incidence business Indocyanine green |
| Zdroj: | ANZ Journal of Surgery. 64:759-762 |
| ISSN: | 1445-2197 1445-1433 |
| Popis: | Impaired hepatic function is a major contributory factor to the high incidence of postoperative morbidity and mortality in patients with malignant biliary obstruction. Dynamic hepatic function tests such as indocyanine green (ICG) retention and aminopyrine breath tests were evaluated in such patients to define whether they were clinically useful for prediction of postoperative morbidity and mortality. Forty-four patients with malignant biliary obstruction undergoing surgery for relief of obstructive jaundice were recruited into the study. Indocyanine green retention and aminopyrine breath tests were carried out in all patients pre-operatively and repeated in 36 patients postoperatively. The ICG retention was abnormal in all patients before surgery and there was significant improvement 2 weeks after surgery (32.8 +/- 2.5% vs 18.3 +/- 2.8%, P = 0.001). The change in ICG retention levels correlated with the serum bilirubin levels but the pre-operative ICG retention value could not predict postoperative morbidity and mortality. The aminopyrine breath test was abnormal in all but one patient. It correlated with pre-operative prothrombin time of the patients before surgery but it did not improve significantly after surgery and was not predictive of postoperative outcome. It is concluded that both ICG retention and aminopyrine breath tests have limited clinical value in the pre-operative evaluation of patients with malignant biliary obstruction. |
| Databáze: | OpenAIRE |
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