Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
| Autor: | Åsmund Avdem Fretland, Serena Elizabeth Marshall, Vegar Johansen Dagenborg, Anne Hansen Ree, Kjetil Boye, Kjersti Flatmark, Eirik Høye, Marius Lund-Iversen, Krzysztof Grzyb, Sheraz Yaqub, Bjørn Edwin, Audun Elnaes Berstad |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Surgical resection Cancer Research Colorectal cancer T-Lymphocytes medicine.medical_treatment T cell t-cell densities colorectal cancer Liver metastases 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols immunogenic cell death Tumor Microenvironment medicine Humans Aged Pharmacology Chemotherapy business.industry Liver Neoplasms Middle Aged medicine.disease Neoadjuvant Therapy 030104 developmental biology medicine.anatomical_structure Oncology Microsatellite Stable 030220 oncology & carcinogenesis Cancer research Molecular Medicine Immunogenic cell death Female Colorectal Neoplasms immune check-point inhibition business Microsatellite Repeats Research Article Research Paper neoadjuvant chemotherapy |
| Zdroj: | Cancer Biology & Therapy article-version (VoR) Version of Record |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.1080/15384047.2020.1721252 |
| Popis: | Patients with colorectal liver metastases (CLM) commonly receive neoadjuvant chemotherapy (NACT) prior to surgical resection. NACT may induce immunogenic cell death with subsequent recruitment of T-cells to the tumor microenvironment, which could be exploited by immune checkpoint inhibition (ICI). In theory, this could expand the use of ICI to obtain responses also in microsatellite stable colorectal cancer, but evidence to suggest optimal treatment schedules are lacking. In this study, densities of total-, cytotoxic-, helper- and regulatory T-cells were quantified by immunohistochemistry in resected CLM from 92 patients included in the OSLO-COMET trial (NCT01516710). All but one patient had microsatellite stable tumors (91/92). Associations between T-cell densities and clinicopathological parameters were analyzed. Fluoropyrimidine-based NACT (in most cases with addition of oxaliplatin or irinotecan) was administered to 45 patients completed median 8 weeks prior to surgical resection. No overall association was found between NACT administration and intratumoral T-cell densities. However, within the NACT group, a short time interval ( |
| Databáze: | OpenAIRE |
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