A new biphenyl and other constituents from the wood of Garcinia schomburgkiana
| Autor: | Chutichot Mungmee, Supotchana Sitthigool, Rutt Suttisri, Anumart Buakeaw |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Cell Survival Xanthones Positive control Plant Science Biochemistry Analytical Chemistry Cell Line chemistry.chemical_compound Benzophenones Xanthone Cytotoxic T cell Organic chemistry Biflavonoids Humans Garcinia schomburgkiana Cytotoxicity Biphenyl Molecular Structure Chemistry Plant Extracts Organic Chemistry Biphenyl Compounds Hep G2 Cells Wood Cell culture Steroids Garcinia |
| Zdroj: | Natural product research. 27(21) |
| ISSN: | 1478-6427 |
| Popis: | A new biphenyl, named schomburgbiphenyl (1), and 14 known compounds were isolated from the wood of Garcinia schomburgkiana. The known constituents were identified as follows: three xanthones (2, 8 and 9), two benzophenones (3 and 4), three biphenyls (5–7), three biflavonoids (10–12) and three steroids. Compounds 3 and 4 were highly cytotoxic to SW620 cell line (100 times more than the positive control, doxorubicin) and were also strongly active against KATO-III, HepG2 and CHAGO cell lines. Compound 6 was specifically cytotoxic towards SW620 cells, whereas compound 8 displayed strong cytotoxicity against all five cell lines tested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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