Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators

Autor:	Shuo, Wang, Yujie, Ren, Qilan, Li, Ya, Wang, Xiangyi, Jiang, Shujing, Xu, Xujie, Zhang, Shujie, Zhao, Daniel P, Bradley, Molly E, Woodson, Fabao, Zhao, Shuo, Wu, Yuhuan, Li, Ye, Tian, Xinyong, Liu, John E, Tavis, Peng, Zhan
Rok vydání:	2022
Předmět:	Hepatitis B virus Capsid Virus Assembly Drug Design Benzamides Organic Chemistry Drug Discovery Humans Capsid Proteins Antiviral Agents Molecular Biology Biochemistry
Zdroj:	Bioorganic Chemistry. 129:106192
ISSN:	0045-2068
Popis:	Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to demonstrate antiviral activity in patients infected with HBV. However, the relatively low aqueous solubility and moderate activity in the human body halted further development of NVR 3-778. To improve the anti-HBV activity and the drug-like properties of NVR 3-778, we designed and synthesized a series of NVR 3-778 derivatives. Notably, phenylboronic acid-bearing compound 7b (EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a16fdb9e703f8f489f7287cf6f5901 https://doi.org/10.1016/j.bioorg.2022.106192 Zobrazit plný text záznamu Full Text from ScienceDirect