Effects of Preoperative Sublingual Misoprostol on Uterine Tone during Isoflurane Anesthesia for Cesarean Section
| Autor: | Osama Warda, Mona S. Ahmady, Mohamed R. El Tahan, Amr M. Yasseen, Amal Rashad, Douaa G. Diab, Mohamed Matter, Eiad A. Ramzy |
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| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Administration Sublingual Hemorrhage Hematocrit Placebo Young Adult Double-Blind Method Pregnancy Oxytocics Preoperative Care medicine Elective Cesarean Delivery Humans Intubation Anesthesia Obstetrical Misoprostol COMPLICAÇÕES Hemorragia ANESTESIA Obstétrica medicine.diagnostic_test Isoflurane business.industry Cesarean Section Uterus ANESTÉSICOS Volatil isoflurano CIRURGIA Cesárea Perioperative medicine.disease Surgery CIRUGÍA Cesárea Uterine atony Anesthesiology and Pain Medicine Anesthesia Anesthetics Inhalation DROGAS misoprostol Female COMPLICACIONES Sangramiento business medicine.drug |
| Zdroj: | Brazilian Journal of Anesthesiology. (5):625-635 |
| ISSN: | 0034-7094 |
| DOI: | 10.1016/S0034-7094(12)70162-9 |
| Popis: | SummaryBackground and objectivesMisoprostol would reduce the uterine bleeding after cesarean delivery without harmful effects on either mother or baby. We aimed to evaluate the effects of preoperative misoprostol on maternal blood loss, uterine tone, and the need for additional oxytocin after cesarean delivery under isoflurane anesthesia.MethodsAfter ethical approval, 366 patients scheduled for elective cesarean delivery were randomly allocated to receive either sublingual misoprostol 400μg (n=179) or placebo tablet (n=187) after intubation. Anesthesia was maintained with 0.5–0.7 MAC isoflurane with nitrous oxide. All patients received intravenous infusion of 10IU of oxytocin after placental delivery. Perioperative estimated blood loss, uterine tone, need for supplementary oxytocin, hematocrit, Apgar scores at 1 and 5 min and adverse effects were recorded.ResultsAfter induction, patients receiving sublingual misoprostol had significant less perioperative estimated blood loss (202±383.1 vs. 708±204.3mL, p |
| Databáze: | OpenAIRE |
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