Increased risk of thyroid disease in Danish women with polycystic ovary syndrome: a cohort study
| Autor: | Dorte Glintborg, Bo Abrahamsen, Mads Nybo, Katrine Hass Rubin, Marianne Andersen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty Goiter Waist endocrine system diseases Endocrinology Diabetes and Metabolism Medicine prescriptions 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Thyroiditis 03 medical and health sciences 0302 clinical medicine Endocrinology ICD-10 Internal Medicine medicine thyroid disease Danish Polycystic ovary syndrome lcsh:RC648-665 030219 obstetrics & reproductive medicine Obstetrics business.industry Research Thyroid disease register based Hazard ratio national nutritional and metabolic diseases National medicine.disease Polycystic ovary female genital diseases and pregnancy complications polycystic ovary syndrome Cohort medicine prescriptions business Register based Cohort study |
| Zdroj: | Endocrine Connections, Vol 8, Iss 10, Pp 1405-1415 (2019) Endocrine Connections Glintborg, D, Rubin, K, Nybo, M, Abrahamsen, B & Andersen, M 2019, ' Increased risk of thyroid disease in Danish women with polycystic ovary syndrome : a cohort study ', Endocrine Connections, vol. 8, no. 10, pp. 1405-1415 . https://doi.org/10.1530/EC-19-0377 |
| ISSN: | 2049-3614 |
| Popis: | Aim To investigate risk of thyroid disease in Danish women with PCOS. Design National register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (PCOS OUH, n = 1146) was an embedded cohort of women with PCOS and clinical and biochemical examination. Three age-matched controls were included for each woman with PCOS (n = 54,757). The main outcome measures were thyroid disease (hypothyroidism, Graves’ disease, goiter, thyroiditis) according to hospital diagnosis codes and/or inferred from filled medicine prescriptions. Associations between baseline TSH and development of cardio-metabolic disease was examined in PCOS OUH. Results The median (quartiles) age at inclusion was 29 (23–35) years and follow-up duration was 11.1 (6.9–16.0) years. The hazard ratio (95% CI) for thyroid disease development was 2.5 (2.3–2.7) (P P n = 133) had higher BMI (median 29 vs 27 kg/m2), wider waist, higher triglycerides and free testosterone by the time of PCOS diagnosis compared to women in PCOS OUH with TSH n = 588). Baseline TSH did not predict later development of cardio-metabolic diseases in PCOS OUH. Conclusions The event rate of thyroid disease was significantly and substantially higher in women with PCOS compared to controls. |
| Databáze: | OpenAIRE |
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