Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans
| Autor: | Martin Sikora, Ceri Falys, Václav Smrčka, Anders J. Hansen, Ron A. M. Fouchier, Jette Arneborg, Karl-Göran Sjögren, Barbara Mühlemann, Sabine Sten, Christian Drosten, Vladimir I. Bazaliiskii, Niels Lynnerup, Wiesław Bogdanowicz, Terry Jones, Kadicha Tashbaeva, Peter de Barros Damgaard, Lasse Vinner, Morten E. Allentoft, Derek J. Smith, Ashot Margaryan, Eske Willerslev, Andrzej W. Weber, Martyna Molak, Kristian Kristiansen, Mikhail V. Sablin |
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| Přispěvatelé: | Virology, Smith, Derek [0000-0002-2393-1890], Willerslev, Eske [0000-0002-7081-6748], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Most recent common ancestor Genotype viruses 030106 microbiology Erythema Infectiosum Genome Viral Biology paleo virology Genome Evolution Molecular 03 medical and health sciences Basal (phylogenetics) Phylogenetics Parvovirus B19 Human Humans ancient DNA Phylogeny Medicinsk genetik virus evolution Multidisciplinary Phylogenetic tree parvovirus B19 History 19th Century Sequence Analysis DNA History 20th Century Biological Sciences 3. Good health virology 030104 developmental biology Ancient DNA Evolutionary biology Viral evolution Medical Genetics |
| Zdroj: | Proceedings of the National Academy of Sciences of the U.S.A., 115(29), 7557-7562. National Academy of Sciences Proceedings of the National Academy of Sciences |
| ISSN: | 0027-8424 |
| Popis: | Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics. |
| Databáze: | OpenAIRE |
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